Anti-IFITM2 Antibody (CAB15133)
- SKU:
- CAB15133
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Frequently bought together:
Description
| 抗体名: | Anti-IFITM2 Antibody |
| 抗体コード: | CAB15133 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human IFITM2 (NP_006426.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human |
| ポジティブサンプル: | HeLa |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human IFITM2 (NP_006426.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MNHI VQTF SPVN SGQP PNYE MLKE EQEV AMLG VPHN PAPP MSTV IHIR SETS VPDH VVWS LFNT LFMN TCCL GFIA FAYS VKSR DRKM VGDV TGAQ AYAS |
| 遺伝子ID: | 10581 |
| Uniprot: | Q01629 |
| セルラーロケーション: | Cell membrane, Single-pass membrane protein |
| 計算された分子量: | 14kDa |
| 観察された分子量: | 17kDa |
| 同義語: | IFITM2, 1-8D, DSPA2c |
| バックグラウンド: |
| UniProt Protein Function: | IFITM2: IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and vesicular stomatitis virus (VSV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry, SARS-CoV S protein-mediated viral entry and VSV G protein- mediated viral entry. Induces cell cycle arrest and mediates apoptosis by caspase activation and in p53-independent manner. Belongs to the CD225/Dispanin family. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Membrane protein, integral Chromosomal Location of Human Ortholog: 11p15.5 Cellular Component: integral to membrane; plasma membrane Biological Process: cytokine and chemokine mediated signaling pathway; defense response to virus; immune response; negative regulation of viral genome replication; negative regulation of virion penetration into host cell; response to virus |
| UniProt Code: | Q01629 |
| NCBI GenInfo Identifier: | 151101191 |
| NCBI Gene ID: | 10581 |
| NCBI Accession: | NP_006426.2 |
| UniProt Secondary Accession: | Q01629,Q6FH82, Q96DA8, |
| UniProt Related Accession: | Q01629 |
| Molecular Weight: | 14,632 Da |
| NCBI Full Name: | interferon-induced transmembrane protein 2 |
| NCBI Synonym Full Names: | interferon induced transmembrane protein 2 |
| NCBI Official Symbol: | IFITM2 |
| NCBI Official Synonym Symbols: | 1-8D; DSPA2c |
| NCBI Protein Information: | interferon-induced transmembrane protein 2 |
| UniProt Protein Name: | Interferon-induced transmembrane protein 2 |
| UniProt Synonym Protein Names: | Dispanin subfamily A member 2c; DSPA2c; Interferon-inducible protein 1-8D |
| UniProt Gene Name: | IFITM2 |
| UniProt Entry Name: | IFM2_HUMAN |
 | Western blot analysis of extracts of HeLa cells, using IFITM2 antibody (CAB15133) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
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