Anti-IFIT2 Antibody (CAB13760)
- SKU:
- CAB13760
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Frequently bought together:
Description
| 抗体名: | Anti-IFIT2 Antibody |
| 抗体コード: | CAB13760 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 273-472 of human IFIT2 (NP_001538.4). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human |
| ポジティブサンプル: | A-431, HepG2 |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 273-472 of human IFIT2 (NP_001538.4). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | ALEY IPNN AYLH CQIG CCYR AKVF QVMN LREN GMYG KRKL LELI GHAV AHLK KADE ANDN LFRV CSIL ASLH ALAD QYED AEYY FQKE FSKE LTPV AKQL LHLR YGNF QLYQ MKCE DKAI HHFI EGVK INQK SREK EKMK DKLQ KIAK MRLS KNGA DSEA LHVL AFLQ ELNE KMQQ ADED SERG LESG SLIP SASS WNGE |
| 遺伝子ID: | 3433 |
| Uniprot: | P09913 |
| セルラーロケーション: | Cytoplasm, Endoplasmic reticulum |
| 計算された分子量: | 54kDa |
| 観察された分子量: | 50kDa |
| 同義語: | IFIT2, G10P2, GARG-39, IFI-54, IFI-54K, IFI54, IFIT-2, ISG-54 K, ISG-54K, ISG54, P54, cig42 |
| バックグラウンド: |
| UniProt Protein Function: | IFIT2: IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2'-O-methylation of the 5' cap. The ribose 2'-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O- methylation (cap snatching mechanism). Can promote apoptosis. Belongs to the IFIT family. |
| UniProt Protein Details: | Protein type:Unknown function Chromosomal Location of Human Ortholog: 10q23.31 Cellular Component: endoplasmic reticulum; cytoplasm; cytosol Molecular Function:protein binding Biological Process: apoptotic mitochondrial changes; positive regulation of apoptosis; cytokine and chemokine mediated signaling pathway; response to virus; negative regulation of protein binding; defense response to virus |
| UniProt Code: | P09913 |
| NCBI GenInfo Identifier: | 153082755 |
| NCBI Gene ID: | 3433 |
| NCBI Accession: | NP_001538.4 |
| UniProt Secondary Accession: | P09913,Q5T767, |
| UniProt Related Accession: | P09913 |
| Molecular Weight: | 54,632 Da |
| NCBI Full Name: | interferon-induced protein with tetratricopeptide repeats 2 |
| NCBI Synonym Full Names: | interferon-induced protein with tetratricopeptide repeats 2 |
| NCBI Official Symbol: | IFIT2 |
| NCBI Official Synonym Symbols: | P54; G10P2; IFI54; ISG54; cig42; IFI-54; IFIT-2; GARG-39; IFI-54K; ISG-54K; ISG-54 K |
| NCBI Protein Information: | interferon-induced protein with tetratricopeptide repeats 2; interferon-induced protein 54; interferon-induced 54 kDa protein; Interferon, alpha-inducible protein (MW 54kD) |
| UniProt Protein Name: | Interferon-induced protein with tetratricopeptide repeats 2 |
| UniProt Synonym Protein Names: | ISG-54 K; Interferon-induced 54 kDa protein; IFI-54K; P54 |
| Protein Family: | Interferon-induced protein with tetratricopeptide repeats |
| UniProt Gene Name: | IFIT2 |
| UniProt Entry Name: | IFIT2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using IFIT2 antibody (CAB13760) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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