| UniProt Protein Function: | ID1: ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transcription, coactivator/corepressor; DNA-binding Chromosomal Location of Human Ortholog: 20q11 Cellular Component: nucleoplasm; Golgi apparatus; nucleus Molecular Function:protein dimerization activity; protein binding; transcription factor activity Biological Process: circadian rhythm; collagen metabolic process; blood vessel endothelial cell migration; transcription, DNA-dependent; protein destabilization; heart development; negative regulation of transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; regulation of angiogenesis; negative regulation of DNA binding; BMP signaling pathway; response to antibiotic; regulation of MAPKKK cascade; transforming growth factor beta receptor signaling pathway; blood vessel morphogenesis; negative regulation of osteoblast differentiation; endothelial cell morphogenesis; angiogenesis; negative regulation of transcription, DNA-dependent; negative regulation of apoptosis |
| NCBI Summary: | The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with members of the basic HLH family of transcription factors. The encoded protein has no DNA binding activity and therefore can inhibit the DNA binding and transcriptional activation ability of basic HLH proteins with which it interacts. This protein may play a role in cell growth, senescence, and differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P41134 |
| NCBI GenInfo Identifier: | 31317297 |
| NCBI Gene ID: | 3397 |
| NCBI Accession: | NP_851998.1 |
| UniProt Secondary Accession: | P41134,O00651, O00652, Q16371, Q16377, Q5TE66, Q5TE67 Q969Z7, Q9H0Z5, Q9H109, A8K537, E1P5L4, |
| UniProt Related Accession: | P41134 |
| Molecular Weight: | 15,586 Da |
| NCBI Full Name: | DNA-binding protein inhibitor ID-1 isoform b |
| NCBI Synonym Full Names: | inhibitor of DNA binding 1, HLH protein |
| NCBI Official Symbol: | ID1 |
| NCBI Official Synonym Symbols: | ID; bHLHb24 |
| NCBI Protein Information: | DNA-binding protein inhibitor ID-1 |
| UniProt Protein Name: | DNA-binding protein inhibitor ID-1 |
| UniProt Synonym Protein Names: | Class B basic helix-loop-helix protein 24; bHLHb24; Inhibitor of DNA binding 1; Inhibitor of differentiation 1 |
| Protein Family: | DNA-binding protein inhibitor |
| UniProt Gene Name: | ID1 |
| UniProt Entry Name: | ID1_HUMAN |
