Anti-Iba1 Antibody (CAB3160)
- SKU:
- CAB3160
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
抗体名: | Anti-Iba1 Antibody |
抗体コード: | CAB3160 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | IHC |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant protein of human Iba1 |
申し込み: | IHC |
推奨希釈: | IHC 1:50 - 1:200 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: |
免疫原: | Recombinant protein of human Iba1 |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | Email for sequence |
遺伝子ID: | 199 |
Uniprot: | P55008 |
セルラーロケーション: | Cell projection, Cytoplasm, Cytoplasmic side, Peripheral membrane protein, cytoskeleton, ruffle membrane |
計算された分子量: | 10kDa/14kDa/16kDa |
観察された分子量: | Refer to figures |
同義語: | AIF1, AIF-1, IBA1, IRT-1, IRT1, Iba1 |
バックグラウンド: | This gene encodes a protein that binds actin and calcium. This gene is induced by cytokines and interferon and may promote macrophage activation and growth of vascular smooth muscle cells and T-lymphocytes. Polymorphisms in this gene may be associated with systemic sclerosis. Alternative splicing results in multiple transcript variants, but the full-length and coding nature of some of these variants is not certain. |
UniProt Protein Function: | AIF1: Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T- lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Cytoskeletal Chromosomal Location of Human Ortholog: 6p21.3 Cellular Component: perinuclear region of cytoplasm; lamellipodium; cytoplasm; actin filament; perikaryon; nucleus; cytosol; phagocytic cup Molecular Function:actin filament binding; calcium ion binding Biological Process: actin filament bundle formation; positive regulation of nitric oxide biosynthetic process; negative regulation of smooth muscle cell proliferation; positive regulation of smooth muscle cell proliferation; microglial cell activation; Rac protein signal transduction; cellular response to hormone stimulus; actin filament polymerization; positive regulation of muscle hyperplasia; cellular response to extracellular stimulus; positive regulation of T cell proliferation; response to axon injury; positive regulation of protein amino acid phosphorylation; phagocytosis, engulfment; response to electrical stimulus; inflammatory response; negative regulation of apoptosis |
NCBI Summary: | This gene encodes a protein that binds actin and calcium. This gene is induced by cytokines and interferon and may promote macrophage activation and growth of vascular smooth muscle cells and T-lymphocytes. Polymorphisms in this gene may be associated with systemic sclerosis. Alternative splicing results in multiple transcript variants, but the full-length and coding nature of some of these variants is not certain. [provided by RefSeq, Jan 2016] |
UniProt Code: | P55008 |
NCBI GenInfo Identifier: | 1703217 |
NCBI Gene ID: | 199 |
NCBI Accession: | P55008.1 |
UniProt Related Accession: | P55008 |
Molecular Weight: | |
NCBI Full Name: | Allograft inflammatory factor 1 |
NCBI Synonym Full Names: | allograft inflammatory factor 1 |
NCBI Official Symbol: | AIF1 |
NCBI Official Synonym Symbols: | IBA1; IRT1; AIF-1; IRT-1 |
NCBI Protein Information: | allograft inflammatory factor 1 |
UniProt Protein Name: | Allograft inflammatory factor 1 |
UniProt Synonym Protein Names: | Ionized calcium-binding adapter molecule 1; Protein G1 |
Protein Family: | Putative apoptosis-inducing factor |
UniProt Gene Name: | AIF1 |
UniProt Entry Name: | AIF1_HUMAN |