| UniProt Protein Function: | AIF1: Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T- lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cytoskeletal Chromosomal Location of Human Ortholog: 6p21.3 Cellular Component: perinuclear region of cytoplasm; lamellipodium; cytoplasm; actin filament; perikaryon; nucleus; cytosol; phagocytic cup Molecular Function:actin filament binding; calcium ion binding Biological Process: actin filament bundle formation; positive regulation of nitric oxide biosynthetic process; negative regulation of smooth muscle cell proliferation; positive regulation of smooth muscle cell proliferation; microglial cell activation; Rac protein signal transduction; cellular response to hormone stimulus; actin filament polymerization; positive regulation of muscle hyperplasia; cellular response to extracellular stimulus; positive regulation of T cell proliferation; response to axon injury; positive regulation of protein amino acid phosphorylation; phagocytosis, engulfment; response to electrical stimulus; inflammatory response; negative regulation of apoptosis |
| NCBI Summary: | This gene encodes a protein that binds actin and calcium. This gene is induced by cytokines and interferon and may promote macrophage activation and growth of vascular smooth muscle cells and T-lymphocytes. Polymorphisms in this gene may be associated with systemic sclerosis. Alternative splicing results in multiple transcript variants, but the full-length and coding nature of some of these variants is not certain. [provided by RefSeq, Jan 2016] |
| UniProt Code: | P55008 |
| NCBI GenInfo Identifier: | 1703217 |
| NCBI Gene ID: | 199 |
| NCBI Accession: | P55008.1 |
| UniProt Related Accession: | P55008 |
| Molecular Weight: | |
| NCBI Full Name: | Allograft inflammatory factor 1 |
| NCBI Synonym Full Names: | allograft inflammatory factor 1 |
| NCBI Official Symbol: | AIF1 |
| NCBI Official Synonym Symbols: | IBA1; IRT1; AIF-1; IRT-1 |
| NCBI Protein Information: | allograft inflammatory factor 1 |
| UniProt Protein Name: | Allograft inflammatory factor 1 |
| UniProt Synonym Protein Names: | Ionized calcium-binding adapter molecule 1; Protein G1 |
| Protein Family: | Putative apoptosis-inducing factor |
| UniProt Gene Name: | AIF1 |
| UniProt Entry Name: | AIF1_HUMAN |
