Anti-IAPP Antibody (CAB2816)
- SKU:
- CAB2816
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-IAPP Antibody |
| 抗体コード: | CAB2816 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | IHC IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic peptide of human IAPP |
| 申し込み: | IHC IF |
| 推奨希釈: | IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: |
| 免疫原: | A synthetic peptide of human IAPP |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 3375 |
| Uniprot: | P10997 |
| セルラーロケーション: | Secreted |
| 計算された分子量: | 9kDa |
| 観察された分子量: | Refer to figures |
| 同義語: | IAPP, DAP, IAP |
| バックグラウンド: | This gene encodes a member of the calcitonin family of peptide hormones. This hormone is released from pancreatic beta cells following food intake to regulate blood glucose levels and act as a satiation signal. Human patients with type 1 and advanced type 2 diabetes exhibit reduced levels of the encoded hormone in blood and pancreas. This protein also exhibits a bactericidal, antimicrobial activity. |
| UniProt Protein Function: | IAPP: Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism. Belongs to the calcitonin family. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 12p12.1 Cellular Component: extracellular space; cell soma; extracellular region Molecular Function:identical protein binding; hormone activity; receptor binding Biological Process: negative regulation of cell differentiation; cell-cell signaling; eating behavior; apoptosis; sensory perception of pain; negative regulation of bone resorption; signal transduction; endocrine pancreas development |
| NCBI Summary: | The protein encoded by this gene is commonly found in pancreatic islets of patients suffering diabetes mellitus type II, or harboring an insulinoma. Studies suggest that this protein, like the related beta-amyloid (Abeta) associated with Alzheimer's disease, can induce apoptotic cell-death in particular cultured cells, an effect that may be relevant to the development of type II diabetes. This protein also exhibits an bactericidal, antimicrobial activity. [provided by RefSeq, Sep 2014] |
| UniProt Code: | P10997 |
| NCBI GenInfo Identifier: | 124006 |
| NCBI Gene ID: | 3375 |
| NCBI Accession: | P10997.1 |
| UniProt Secondary Accession: | P10997,Q0ZD87, Q14598, |
| UniProt Related Accession: | P10997 |
| Molecular Weight: | 89 |
| NCBI Full Name: | Islet amyloid polypeptide |
| NCBI Synonym Full Names: | islet amyloid polypeptide |
| NCBI Official Symbol: | IAPP |
| NCBI Official Synonym Symbols: | DAP; IAP |
| NCBI Protein Information: | islet amyloid polypeptide; amylin; insulinoma amyloid peptide; diabetes-associated peptide; Islet amyloid polypeptide (diabetes-associated peptide; amylin) |
| UniProt Protein Name: | Islet amyloid polypeptide |
| UniProt Synonym Protein Names: | Amylin; Diabetes-associated peptide; DAP; Insulinoma amyloid peptide |
| Protein Family: | Islet amyloid polypeptide |
| UniProt Gene Name: | IAPP |
| UniProt Entry Name: | IAPP_HUMAN |
 | Immunohistochemistry of paraffin-embedded Rat pancreas using IAPP Rabbit pAb (CAB2816) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded Mouse pancreas using IAPP Rabbit pAb (CAB2816) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of rat pancreas using IAPP antibody (CAB2816) at dilution of 1:100. Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of mouse pancreas using IAPP antibody (CAB2816) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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