Anti-HTRA4 Antibody (CAB14314)
- SKU:
- CAB14314
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-HTRA4 Antibody |
| 抗体コード: | CAB14314 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 32-200 of human HTRA4 (NP_710159.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | U-87MG, U-251MG, Mouse brain, Rat brain |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 32-200 of human HTRA4 (NP_710159.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | EKLH TQPS CPAV CQPT RCPA LPTC ALGT TPVF DLCR CCRV CPAA EREV CGGA QGQP CAPG LQCL QPLR PGFP STCG CPTL GGAV CGSD RRTY PSMC ALRA ENRA ARRL GKVP AVPV QWGN CGDT GTRS AGPL RRNY NFIA AVVE KVAP SVVH VQLW GRLL HGSR LVPV Y |
| 遺伝子ID: | 203100 |
| Uniprot: | P83105 |
| セルラーロケーション: | Secreted |
| 計算された分子量: | 50kDa |
| 観察された分子量: | 51kDa |
| 同義語: | HTRA4 |
| バックグラウンド: | This gene encodes a member of the HtrA family of proteases. The encoded protein contains a putative signal peptide, an insulin growth factor binding domain, a Kazal protease inhibitor domain, a conserved trypsin domain and a PDZ domain. Based on studies on other related family members, this enzyme may function as a secreted oligomeric chaperone protease to degrade misfolded secretory proteins. Other human HtrA proteins have been implicated in arthritis, tumor suppression, unfolded stress response, apoptosis, and aging. |
| UniProt Protein Function: | HTRA4: Serine protease (Probable). Belongs to the peptidase S1B family. |
| UniProt Protein Details: | Protein type:Protease; Secreted, signal peptide; Secreted; EC 3.4.21.- Chromosomal Location of Human Ortholog: 8p11.22 Cellular Component: extracellular region Molecular Function:insulin-like growth factor binding; serine-type endopeptidase activity; endopeptidase activity Biological Process: regulation of cell growth; proteolysis; negative regulation of transforming growth factor beta receptor signaling pathway |
| NCBI Summary: | This gene encodes a member of the HtrA family of proteases. The encoded protein contains a putative signal peptide, an insulin growth factor binding domain, a Kazal protease inhibitor domain, a conserved trypsin domain and a PDZ domain. Based on studies on other related family members, this enzyme may function as a secreted oligomeric chaperone protease to degrade misfolded secretory proteins. Other human HtrA proteins have been implicated in arthritis, tumor suppression, unfolded stress response, apoptosis, and aging. [provided by RefSeq, Oct 2008] |
| UniProt Code: | P83105 |
| NCBI GenInfo Identifier: | 35505491 |
| NCBI Gene ID: | 203100 |
| NCBI Accession: | AAH57765.1 |
| UniProt Secondary Accession: | P83105,Q542Z4, Q6PF13, |
| UniProt Related Accession: | P83105 |
| Molecular Weight: | 50,979 Da |
| NCBI Full Name: | HtrA serine peptidase 4 |
| NCBI Synonym Full Names: | HtrA serine peptidase 4 |
| NCBI Official Symbol: | HTRA4 |
| NCBI Protein Information: | serine protease HTRA4; probable serine protease HTRA4; high-temperature requirement factor A4 |
| UniProt Protein Name: | Serine protease HTRA4 |
| UniProt Synonym Protein Names: | High-temperature requirement factor A4 |
| Protein Family: | Serine protease |
| UniProt Gene Name: | HTRA4 |
| UniProt Entry Name: | HTRA4_HUMAN |
 | Western blot analysis of extracts of various cell lines, using HTRA4 antibody (CAB14314) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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