Anti-HTRA3 Antibody (CAB14649)
- SKU:
- CAB14649
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-HTRA3 Antibody |
| 抗体コード: | CAB14649 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 334-453 of human HTRA3 (NP_444272.1). |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | HeLa, SW480, Mouse brain, Mouse heart, Rat brain |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 334-453 of human HTRA3 (NP_444272.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | SDRI TRFL TEFQ DKQI KDWK KRFI GIRM RTIT PSLV DELK ASNP DFPE VSSG IYVQ EVAP NSPS QRGG IQDG DIIV KVNG RPLV DSSE LQEA VLTE SPLL LEVR RGND DLLF SIAP EVVM |
| 遺伝子ID: | 94031 |
| Uniprot: | P83110 |
| セルラーロケーション: | Secreted |
| 計算された分子量: | 37kDa/48kDa |
| 観察された分子量: | 48kDa |
| 同義語: | HTRA3, Prsp, Tasp |
| バックグラウンド: |
| UniProt Protein Function: | HTRA3: Serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans such as decorin/DCN, biglycan/BGN and fibronectin/FN1. Inhibits signaling mediated by TGF-beta family proteins possibly indirectly by degradation of these ECM proteoglycans. May act as a tumor suppressor. Negatively regulates, in vitro, trophoblast invasion during placental development and may be involved in the development of the placenta in vivo. May also have a role in ovarian development, granulosa cell differentiation and luteinization. Belongs to the peptidase S1B family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; EC 3.4.21.-; Secreted; Protease Chromosomal Location of Human Ortholog: 4p16.1 Molecular Function:endopeptidase activity; protein binding; serine-type peptidase activity Biological Process: negative regulation of BMP signaling pathway; negative regulation of transforming growth factor beta receptor signaling pathway; proteolysis |
| UniProt Code: | P83110 |
| NCBI GenInfo Identifier: | 21542412 |
| NCBI Gene ID: | 94031 |
| NCBI Accession: | P83110.2 |
| UniProt Secondary Accession: | P83110,Q7Z7A2, |
| UniProt Related Accession: | P83110 |
| Molecular Weight: | 37,940 Da |
| NCBI Full Name: | Serine protease HTRA3 |
| NCBI Synonym Full Names: | HtrA serine peptidase 3 |
| NCBI Official Symbol: | HTRA3 |
| NCBI Official Synonym Symbols: | Prsp; Tasp |
| NCBI Protein Information: | serine protease HTRA3 |
| UniProt Protein Name: | Serine protease HTRA3 |
| UniProt Synonym Protein Names: | High-temperature requirement factor A3; Pregnancy-related serine protease |
| Protein Family: | Serine protease |
| UniProt Gene Name: | HTRA3 |
| UniProt Entry Name: | HTRA3_HUMAN |
 | Western blot analysis of extracts of various cell lines, using HTRA3 antibody (CAB14649) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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