Anti-HTATIP2 Antibody (CAB5816)
- SKU:
- CAB5816
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cardiovascular
Frequently bought together:
Description
| 抗体名: | Anti-HTATIP2 Antibody |
| 抗体コード: | CAB5816 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 100 to the C-terminus of human HTATIP2 (NP_006401.3). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human |
| ポジティブサンプル: | LO2 |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 100 to the C-terminus of human HTATIP2 (NP_006401.3). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | GAEG FVRV DRDY VLKS AELA KAGG CKHF NLLS SKGA DKSS NFLY LQVK GEVE AKVE ELKF DRYS VFRP GVLL CDRQ ESRP GEWL VRKF FGSL PDSW ASGH SVPV VTVV RAML NNVV RPRD KQME LLEN KAIH DLGK AHGS LKP |
| 遺伝子ID: | 10553 |
| Uniprot: | Q9BUP3 |
| セルラーロケーション: | Cytoplasm, Nucleus envelope |
| 計算された分子量: | 14kDa/27kDa/30kDa |
| 観察された分子量: | 27kDa |
| 同義語: | HTATIP2, CC3, SDR44U1, TIP30 |
| バックグラウンド: |
| UniProt Protein Function: | HTATIP2: Oxidoreductase required for tumor suppression. NAPDH- bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import. Isoform 1 is a metastasis suppressor with proapoptotic as well as antiangiogenic properties. Isoform 2 has an antiapoptotic effect. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Oxidoreductase; Apoptosis; Tumor suppressor; Nuclear envelope; Transcription factor; EC 1.1.1.- Chromosomal Location of Human Ortholog: 11p15.1 Cellular Component: membrane; cytoplasm; nuclear envelope; nucleus Molecular Function:protein binding; transcription coactivator activity; oxidoreductase activity Biological Process: regulation of transcription from RNA polymerase II promoter; viral reproduction; apoptosis; nuclear import; angiogenesis; cell differentiation; regulation of angiogenesis; negative regulation of apoptosis |
| UniProt Code: | Q9BUP3 |
| NCBI GenInfo Identifier: | 317373366 |
| NCBI Gene ID: | 10553 |
| NCBI Accession: | Q9BUP3.2 |
| UniProt Secondary Accession: | Q9BUP3,O15383, O60520, O95345, Q53GC1, Q53GG2, Q6IBI3 A8K7S7, D3DQY8, |
| UniProt Related Accession: | Q9BUP3 |
| Molecular Weight: | 242 |
| NCBI Full Name: | Oxidoreductase HTATIP2 |
| NCBI Synonym Full Names: | HIV-1 Tat interactive protein 2, 30kDa |
| NCBI Official Symbol: | HTATIP2 |
| NCBI Official Synonym Symbols: | CC3; TIP30; SDR44U1 |
| NCBI Protein Information: | oxidoreductase HTATIP2; Tat-interacting protein (30kD); HIV-1 TAT-interactive protein 2; 30 kDa HIV-1 TAT-interacting protein; short chain dehydrogenase/reductase family 44U, member 1 |
| UniProt Protein Name: | Oxidoreductase HTATIP2 |
| UniProt Synonym Protein Names: | 30 kDa HIV-1 TAT-interacting protein; HIV-1 TAT-interactive protein 2 |
| Protein Family: | Oxidoreductase |
| UniProt Gene Name: | HTATIP2 |
| UniProt Entry Name: | HTAI2_HUMAN |
 | Western blot analysis of extracts of LO2 cells, using HTATIP2 antibody (CAB5816) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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