| UniProt Protein Function: | HSH2: May be a modulator of the apoptotic response through its ability to affect mitochondrial stability. Adapter protein involved in tyrosine kinase and CD28 signaling. Seems to affect CD28-mediated activation of the RE/AP element of the interleukin-2 promoter. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 19p13.11 Molecular Function:protein binding |
| NCBI Summary: | T-cell activation requires 2 signals: recognition of antigen by the T-cell receptor (see TCR; MIM 186880) and a costimulatory signal provided primarily by CD28 (MIM 186760) in naive T cells. HSH2 is a target of both of these signaling pathways (Greene et al., 2003 [PubMed 12960172]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q96JZ2 |
| NCBI GenInfo Identifier: | 16877105 |
| NCBI Gene ID: | 84941 |
| NCBI Accession: | AAH16826.1 |
| UniProt Secondary Accession: | Q96JZ2,Q6ZNG7, B5ME72, |
| UniProt Related Accession: | Q96JZ2 |
| Molecular Weight: | 32,704 Da |
| NCBI Full Name: | HSH2D protein, partial |
| NCBI Synonym Full Names: | hematopoietic SH2 domain containing |
| NCBI Official Symbol: | HSH2D |
| NCBI Official Synonym Symbols: | ALX; HSH2 |
| NCBI Protein Information: | hematopoietic SH2 domain-containing protein |
| UniProt Protein Name: | Hematopoietic SH2 domain-containing protein |
| UniProt Synonym Protein Names: | Adaptor in lymphocytes of unknown function X |
| Protein Family: | Hematopoietic SH2 domain-containing protein |
| UniProt Gene Name: | HSH2D |
