Anti-HS2ST1 Antibody (CAB13837)
- SKU:
- CAB13837
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-HS2ST1 Antibody |
| 抗体コード: | CAB13837 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-229 of human HS2ST1 (NP_001127964.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | U-87MG, Mouse lung, Rat thymus |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-229 of human HS2ST1 (NP_001127964.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MGLL RIMM PPKL QLLA VVAF AVAM LFLE NQIQ KLEE SRSK LERA IARH EVRE IEQR HTMD GPRQ DATL DEEE DMVI IYNR VPKT ASTS FTNI AYDL CAKN KYHV LHIN TTKN NPVM SLQD QVRF VKNI TSWK EMKP GFYH GHVS YLDF AKFG VKKK PIYI NVIR DPIE RLVS YYYF LRFG DDYR PGLR RRKQ GDKK TFDE CVAE GGSD CAPE KLWL QIPF FCGH SSEC W |
| 遺伝子ID: | 9653 |
| Uniprot: | Q7LGA3 |
| セルラーロケーション: | Golgi apparatus membrane, Single-pass type II membrane protein |
| 計算された分子量: | 26kDa/34kDa/41kDa |
| 観察された分子量: | 42kDa |
| 同義語: | HS2ST1, dJ604K5.2 |
| バックグラウンド: | Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. This gene encodes a member of the heparan sulfate biosynthetic enzyme family that transfers sulfate to the 2 position of the iduronic acid residue of heparan sulfate. The disruption of this gene resulted in no kidney formation in knockout embryonic mice, indicating that the absence of this enzyme may interfere with the signaling required for kidney formation. Two alternatively spliced transcript variants that encode different proteins have been found for this gene. |
| UniProt Protein Function: | HS2ST1: Catalyzes the transfer of sulfate to the C2-position of selected hexuronic acid residues within the maturing heparan sulfate (HS). 2-O-sulfation within HS, particularly of iduronate residues, is essential for HS to participate in a variety of high- affinity ligand-binding interactions and signaling processes. Mediates 2-O-sulfation of both L-iduronyl and D-glucuronyl residues. Belongs to the sulfotransferase 3 family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Membrane protein, integral; Glycan Metabolism - heparan sulfate biosynthesis; EC 2.8.2.-; Transferase Chromosomal Location of Human Ortholog: 1p22.3 Cellular Component: Golgi membrane; membrane Molecular Function:heparan sulfate 2-O-sulfotransferase activity Biological Process: glycosaminoglycan biosynthetic process |
| NCBI Summary: | Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. This gene encodes a member of the heparan sulfate biosynthetic enzyme family that transfers sulfate to the 2 position of the iduronic acid residue of heparan sulfate. The disruption of this gene resulted in no kidney formation in knockout embryonic mice, indicating that the absence of this enzyme may interfere with the signaling required for kidney formation. Two alternatively spliced transcript variants that encode different proteins have been found for this gene. [provided by RefSeq, Aug 2008] |
| UniProt Code: | Q7LGA3 |
| NCBI GenInfo Identifier: | 68052326 |
| NCBI Gene ID: | 9653 |
| NCBI Accession: | Q7LGA3.1 |
| UniProt Secondary Accession: | Q7LGA3,O75036, Q32NB5, Q8TAC5, Q9H441, Q9NUJ9, D3DT22 |
| UniProt Related Accession: | Q7LGA3 |
| Molecular Weight: | 26,757 Da |
| NCBI Full Name: | Heparan sulfate 2-O-sulfotransferase 1 |
| NCBI Synonym Full Names: | heparan sulfate 2-O-sulfotransferase 1 |
| NCBI Official Symbol: | HS2ST1 |
| NCBI Official Synonym Symbols: | dJ604K5.2 |
| NCBI Protein Information: | heparan sulfate 2-O-sulfotransferase 1 |
| UniProt Protein Name: | Heparan sulfate 2-O-sulfotransferase 1 |
| Protein Family: | Heparan sulfate 2-O-sulfotransferase |
| UniProt Gene Name: | HS2ST1 |
| UniProt Entry Name: | HS2ST_HUMAN |
 | Western blot analysis of extracts of various cell lines, using HS2ST1 antibody (CAB13837) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
View AllClose