Anti-HRH2 Antibody (CAB14170)
- SKU:
- CAB14170
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-HRH2 Antibody |
| 抗体コード: | CAB14170 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 150-250 of human HRH2 (NP_001124527.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | LO2, A-431, Mouse skeletal muscle |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 150-250 of human HRH2 (NP_001124527.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | SFLS IHLG WNSR NETS KGNH TTSK CKVQ VNEV YGLV DGLV TFYL PLLI MCIT YYRI FKVA RDQA KRIN HISS WKAA TIRE HKAT VTLA AVMG AFII CWFP Y |
| 遺伝子ID: | 3274 |
| Uniprot: | P25021 |
| セルラーロケーション: | Cell membrane, Multi-pass membrane protein |
| 計算された分子量: | 40kDa/44kDa |
| 観察された分子量: | 38kDa |
| 同義語: | HRH2, H2R |
| バックグラウンド: | Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. Histamine receptor H2 belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and stimulates gastric acid secretion. It also regulates gastrointestinal motility and intestinal secretion and is thought to be involved in regulating cell growth and differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | H2R: The H2 subclass of histamine receptors mediates gastric acid secretion. Also appears to regulate gastrointestinal motility and intestinal secretion. Possible role in regulating cell growth and differentiation. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and, through a separate G protein-dependent mechanism, the phosphoinositide/protein kinase (PKC) signaling pathway. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 1 Chromosomal Location of Human Ortholog: 5q35.2 Cellular Component: integral to plasma membrane; plasma membrane Biological Process: G-protein signaling, coupled to cyclic nucleotide second messenger; immune response |
| NCBI Summary: | Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. Histamine receptor H2 belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and stimulates gastric acid secretion. It also regulates gastrointestinal motility and intestinal secretion and is thought to be involved in regulating cell growth and differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008] |
| UniProt Code: | P25021 |
| NCBI GenInfo Identifier: | 123120 |
| NCBI Gene ID: | 3274 |
| NCBI Accession: | P25021.1 |
| UniProt Secondary Accession: | P25021,Q14464, Q7Z5R9, B5BUP7, |
| UniProt Related Accession: | P25021 |
| Molecular Weight: | 44,541 Da |
| NCBI Full Name: | Histamine H2 receptor |
| NCBI Synonym Full Names: | histamine receptor H2 |
| NCBI Official Symbol: | HRH2 |
| NCBI Official Synonym Symbols: | H2R |
| NCBI Protein Information: | histamine H2 receptor |
| UniProt Protein Name: | Histamine H2 receptor |
| UniProt Synonym Protein Names: | Gastric receptor I |
| Protein Family: | Histamine H2 receptor |
| UniProt Gene Name: | HRH2 |
| UniProt Entry Name: | HRH2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using HRH2 antibody (CAB14170) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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