Anti-HOXD10 Antibody (CAB7686)
- SKU:
- CAB7686
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
| 抗体名: | Anti-HOXD10 Antibody |
| 抗体コード: | CAB7686 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human HOXD10 (NP_002139.2). |
| 申し込み: | WB IF |
| 推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | Mouse kidney, Mouse heart, Rat heart |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human HOXD10 (NP_002139.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MSFP NSSP AANT FLVD SLIS ACRS DSFY SSSA SMYM PPPS ADMG TYGM QTCG LLPS LAKR EVNH QNMG MNVH PYIP QVDS WTDP NRSC RIEQ PVTQ QVPT CSFT TNIK EESN CCMY SDKR NKLI SAEV PSYQ RLVP ESCP VENP EVPV PGYF RLSQ TYAT GKTQ EYNN SPEG SSTV MLQL NPRG AAKP QLSA AQLQ MEKK MNEP VSGQ EPTK VSQV ESPE AKGG LPEE RSCL AEVS VSSP |
| 遺伝子ID: | 3236 |
| Uniprot: | P28358 |
| セルラーロケーション: | Nucleus |
| 計算された分子量: | 38kDa |
| 観察された分子量: | 38kDa |
| 同義語: | HOXD10, HOX4, HOX4D, HOX4E, Hox-4.4 |
| バックグラウンド: | This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox D genes located on chromosome 2. The encoded nuclear protein functions as a sequence-specific transcription factor that is expressed in the developing limb buds and is involved in differentiation and limb development. Mutations in this gene have been associated with Wilm's tumor and congenital vertical talus (also known as 'rocker-bottom foot' deformity or congenital convex pes valgus) and/or a foot deformity resembling that seen in Charcot-Marie-Tooth disease. |
| UniProt Protein Function: | HOXD10: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Defects in HOXD10 are a cause of congenital vertical talus (CVT); also known as rocker-bottom foot deformity or congenital convex pes valgus. CVT is a dislocation of the talonavicular joint, with rigid dorsal dislocation of the navicular over the neck of the talus. This condition is usually associated with multiple other congenital deformities and only rarely is an isolated deformity. Belongs to the Abd-B homeobox family. |
| UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: 2q31.1 Disease: Vertical Talus, Congenital |
| NCBI Summary: | This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox D genes located on chromosome 2. The encoded nuclear protein functions as a sequence-specific transcription factor that is expressed in the developing limb buds and is involved in differentiation and limb development. Mutations in this gene have been associated with Wilm's tumor and congenital vertical talus (also known as "rocker-bottom foot" deformity or congenital convex pes valgus) and/or a foot deformity resembling that seen in Charcot-Marie-Tooth disease. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P28358 |
| NCBI GenInfo Identifier: | 143811403 |
| NCBI Gene ID: | 3236 |
| NCBI Accession: | P28358.2 |
| UniProt Secondary Accession: | P28358,Q6NT10, |
| UniProt Related Accession: | P28358 |
| Molecular Weight: | 38,411 Da |
| NCBI Full Name: | Homeobox protein Hox-D10 |
| NCBI Synonym Full Names: | homeobox D10 |
| NCBI Official Symbol: | HOXD10 |
| NCBI Official Synonym Symbols: | HOX4; HOX4D; HOX4E; Hox-4.4 |
| NCBI Protein Information: | homeobox protein Hox-D10 |
| UniProt Protein Name: | Homeobox protein Hox-D10 |
| UniProt Synonym Protein Names: | Homeobox protein Hox-4D; Homeobox protein Hox-4E |
| Protein Family: | Homeobox protein |
| UniProt Gene Name: | HOXD10 |
| UniProt Entry Name: | HXD10_HUMAN |
 | Western blot analysis of extracts of various cell lines, using HOXD10 antibody (CAB7686) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunofluorescence analysis of U2OS cells using HOXD10 antibody (CAB7686) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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