Anti-HOXA1 Antibody (CAB6924)
- SKU:
- CAB6924
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
| 抗体名: | Anti-HOXA1 Antibody |
| 抗体コード: | CAB6924 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 75-205 of human HOXA1 (NP_005513.1). |
| 申し込み: | WB IF |
| 推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:100 |
| 反応性: | Human |
| ポジティブサンプル: | A-431, HT-1080, HeLa, DU145 |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 75-205 of human HOXA1 (NP_005513.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | PQPA TYQT SGNL GVSY SHSS CGPS YGSQ NFSA PYSP YALN QEAD VSGG YPQC APAV YSGN LSSP MVQH HHHH QGYA GGAV GSPQ YIHH SYGQ EHQS LALA TYNN SLSP LHAS HQEA CRSP ASET SSPA QTF |
| 遺伝子ID: | 3198 |
| Uniprot: | P49639 |
| セルラーロケーション: | Nucleus |
| 計算された分子量: | 14kDa/24kDa/36kDa |
| 観察された分子量: | 37kDa |
| 同義語: | HOXA1, BSAS, HOX1, HOX1F |
| バックグラウンド: | In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. The encoded protein may be involved in the placement of hindbrain segments in the proper location along the anterior-posterior axis during development. Two transcript variants encoding two different isoforms have been found for this gene, with only one of the isoforms containing the homeodomain region. |
| UniProt Protein Function: | HOXA1: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures. Seems to act in the maintenance and/or generation of hindbrain segments. Defects in HOXA1 are the cause of Athabaskan brainstem dysgenesis syndrome (ABDS); also known as Narvajo brainstem syndrome. This syndrome is characterized by horizontal gaze palsy, sensorineural deafness, central hypoventilation, and developmental delay. Some patients had swallowing dysfunction, vocal cord paralysis, facial paresis, seizures, and cardiac outflow tract anomalies. Defects in HOXA1 are the cause of Bosley-Salih-Alorainy syndrome (BSAS). Affected individuals show horizontal gaze abnormalities, deafness, facial weakness, vascular malformations of the internal carotid arteries and cardiac outflow trac. Some patients manifest mental retardation and autism spectrum disorder. In contrast to individuals with ABSD, central hypoventilation is not observed in individuals with BSAS. Belongs to the Antp homeobox family. Labial subfamily. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Oncoprotein; DNA-binding; Transcription factor Chromosomal Location of Human Ortholog: 7p15.3 Molecular Function:protein binding Biological Process: abducens nerve formation; anatomical structure morphogenesis; artery morphogenesis; cognition; embryonic neurocranium morphogenesis; inner ear development; multicellular organismal development; neuromuscular process; optokinetic behavior; outer ear morphogenesis; regulation of behavior; sensory perception of sound Disease: Athabaskan Brainstem Dysgenesis Syndrome |
| NCBI Summary: | In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. The encoded protein may be involved in the placement of hindbrain segments in the proper location along the anterior-posterior axis during development. Two transcript variants encoding two different isoforms have been found for this gene, with only one of the isoforms containing the homeodomain region. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P49639 |
| NCBI GenInfo Identifier: | 6166216 |
| NCBI Gene ID: | 3198 |
| NCBI Accession: | P49639.2 |
| UniProt Secondary Accession: | P49639,O43363, A4D184, B2R8U7, |
| UniProt Related Accession: | P49639 |
| Molecular Weight: | 24,489 Da |
| NCBI Full Name: | Homeobox protein Hox-A1 |
| NCBI Synonym Full Names: | homeobox A1 |
| NCBI Official Symbol: | HOXA1 |
| NCBI Official Synonym Symbols: | BSAS; HOX1; HOX1F |
| NCBI Protein Information: | homeobox protein Hox-A1 |
| UniProt Protein Name: | Homeobox protein Hox-A1 |
| UniProt Synonym Protein Names: | Homeobox protein Hox-1F |
| Protein Family: | Homeobox protein |
| UniProt Gene Name: | HOXA1 |
| UniProt Entry Name: | HXA1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using HOXA1 antibody (CAB6924) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
 | Immunofluorescence analysis of MCF7 cells using HOXA1 antibody (CAB6924). Blue: DAPI for nuclear staining. |
View AllClose