Anti-HMOX2 Antibody (CAB12713)
- SKU:
- CAB12713
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-HMOX2 Antibody |
| 抗体コード: | CAB12713 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human HMOX2 (NP_002125.3). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:1000 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | 293T, A-549, SKOV3, HT-29, LO2, Mouse kidney |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human HMOX2 (NP_002125.3). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MSAE VETS EGVD ESEK KNSG ALEK ENQM RMAD LSEL LKEG TKEA HDRA ENTQ FVKD FLKG NIKK ELFK LATT ALYF TYSA LEEE MERN KDHP AFAP LYFP MELH RKEA LTKD MEYF FGEN WEEQ VQCP KAAQ KYVE RIHY IGQN EPEL LVAH AYTR YMGD LSGG QVLK KVAQ RALK LPST GEGT QFYL FENV DNAQ QFKQ LYRA RMNA LDLN MKTK ERIV EEAN KAFE YNMQ IFNE LDQA GSTL ARET LEDG FPVH DGKG DMRK CPFY AA |
| 遺伝子ID: | 3163 |
| Uniprot: | P30519 |
| セルラーロケーション: | Endoplasmic reticulum, Microsome |
| 計算された分子量: | 32kDa/36kDa |
| 観察された分子量: | 36kDa |
| 同義語: | HMOX2, HO-2 |
| バックグラウンド: | Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. Several alternatively spliced transcript variants encoding three different isoforms have been found for this gene. |
| UniProt Protein Function: | HMOX2: Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme oxygenase 2 could be implicated in the production of carbon monoxide in brain where it could act as a neurotransmitter. Belongs to the heme oxygenase family. |
| UniProt Protein Details: | Protein type:Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; EC 1.14.99.3; Endoplasmic reticulum; Oxidoreductase Chromosomal Location of Human Ortholog: 16p13.3 Cellular Component: endoplasmic reticulum membrane; membrane; plasma membrane Molecular Function:heme binding; heme oxygenase (decyclizing) activity; protein binding Biological Process: cellular iron ion homeostasis; heme catabolic process; heme oxidation; iron ion homeostasis; response to hypoxia; response to oxidative stress |
| NCBI Summary: | Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. Several alternatively spliced transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Oct 2013] |
| UniProt Code: | P30519 |
| NCBI GenInfo Identifier: | 1170328 |
| NCBI Gene ID: | 3163 |
| NCBI Accession: | P30519.2 |
| UniProt Secondary Accession: | P30519,O60605, A8MT35, D3DUD5, I3L430, |
| UniProt Related Accession: | P30519 |
| Molecular Weight: | 32,837 Da |
| NCBI Full Name: | Heme oxygenase 2 |
| NCBI Synonym Full Names: | heme oxygenase 2 |
| NCBI Official Symbol: | HMOX2 |
| NCBI Official Synonym Symbols: | HO-2 |
| NCBI Protein Information: | heme oxygenase 2 |
| UniProt Protein Name: | Heme oxygenase 2 |
| UniProt Gene Name: | HMOX2 |
 | Western blot analysis of extracts of various cell lines, using HMOX2 antibody (CAB12713) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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