Anti-HMMR Antibody (CAB12445)[KO Validated]
![Anti-HMMR Antibody (CAB12445)[KO Validated]](https://cdn11.bigcommerce.com/s-d5atsu6k01/images/stencil/608x608/products/18175/18042/anti-hmmr-antibody-cab12445ko-validated__74819__83766.1645803899.jpg?c=1 "Anti-HMMR Antibody (CAB12445)[KO Validated]")
- SKU:
- CAB12445
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
![Anti-HMMR Antibody (CAB12445)[KO Validated]](https://cdn11.bigcommerce.com/s-d5atsu6k01/images/stencil/1280x1280/products/18175/18042/anti-hmmr-antibody-cab12445ko-validated__74819__83766.1645803899.jpg?c=1&imbypass=on "Anti-HMMR Antibody (CAB12445)[KO Validated]")
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Description
| 抗体名: | Anti-HMMR Antibody [KO Validated] |
| 抗体コード: | CAB12445 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human HMMR (NP_001136028.1). |
| 申し込み: | WB IF |
| 推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| 反応性: | Human |
| ポジティブサンプル: | SW480, HeLa, Jurkat, ES-2 |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human HMMR (NP_001136028.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MSFP KAPL KRFN DPSG CAPS PGAY DVKT LEVL KGPV SFQK SQRF KQQK ESKQ NLNV DKDT TLPA SARK VKSS ESKK ESQK NDKD LKIL EKEI RVLL QERG AQDR RIQD LETE LEKM EARL NAAL REKT SLSA NNAT LEKQ LIEL TRTN ELLK SKFS ENGN QKNL RILS LELM KLRN KRET KMRG MMAK QEGM EMKL QVTQ RSLE ESQG KIAQ LEGK LVSI EKEK IDEK SETE KLLE YIEE ISCA SDQV EKYK LDIA QLEE NLKE KNDE ILSL KQSL EENI VILS KQVE DLNV KCQL LEKE |
| 遺伝子ID: | 3161 |
| Uniprot: | O75330 |
| セルラーロケーション: | Cell surface, Cytoplasm |
| 計算された分子量: | 74kDa/82kDa/84kDa |
| 観察された分子量: | 84kDa |
| 同義語: | HMMR, CD168, IHABP, RHAMM |
| バックグラウンド: | The protein encoded by this gene is involved in cell motility. It is expressed in breast tissue and together with other proteins, it forms a complex with BRCA1 and BRCA2, thus is potentially associated with higher risk of breast cancer. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. |
| UniProt Protein Function: | HMMR: Involved in cell motility. When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular- regulated kinase (ERK) activity. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Receptor, misc. Chromosomal Location of Human Ortholog: 5q34 Cellular Component: cell surface; membrane; cytoplasm; plasma membrane Molecular Function:hyaluronic acid binding Biological Process: glycosaminoglycan metabolic process; carbohydrate metabolic process; pathogenesis; hyaluronan metabolic process; hyaluronan catabolic process Disease: Breast Cancer |
| NCBI Summary: | The protein encoded by this gene is involved in cell motility. It is expressed in breast tissue and together with other proteins, it forms a complex with BRCA1 and BRCA2, thus is potentially associated with higher risk of breast cancer. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Dec 2008] |
| UniProt Code: | O75330 |
| NCBI GenInfo Identifier: | 145559482 |
| NCBI Gene ID: | 3161 |
| NCBI Accession: | O75330.2 |
| UniProt Secondary Accession: | O75330,Q32N02, Q92767, A8K3G2, B4E114, D3DQK9, D3DQL0 E9PCS0, |
| UniProt Related Accession: | O75330 |
| Molecular Weight: | |
| NCBI Full Name: | Hyaluronan mediated motility receptor |
| NCBI Synonym Full Names: | hyaluronan-mediated motility receptor (RHAMM) |
| NCBI Official Symbol: | HMMR |
| NCBI Official Synonym Symbols: | CD168; IHABP; RHAMM |
| NCBI Protein Information: | hyaluronan mediated motility receptor; receptor for hyaluronan-mediated motility; intracellular hyaluronic acid-binding protein |
| UniProt Protein Name: | Hyaluronan mediated motility receptor |
| UniProt Synonym Protein Names: | Intracellular hyaluronic acid-binding protein; Receptor for hyaluronan-mediated motility; CD_antigen: CD168 |
| Protein Family: | Hyaluronan mediated motility receptor |
| UniProt Gene Name: | HMMR |
| UniProt Entry Name: | HMMR_HUMAN |
![Anti-HMMR Antibody [KO Validated] (CAB12445)](https://cdn11.bigcommerce.com/s-h68l9z2lnx/product_images/n/442/A12445_1__54947.jpg) | Western blot analysis of extracts of various cell lines, using HMMR antibody (CAB12445) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
![Anti-HMMR Antibody [KO Validated] (CAB12445)](https://cdn11.bigcommerce.com/s-h68l9z2lnx/product_images/i/285/A12445_2__12186.jpg) | Western blot analysis of extracts from normal (control) and HMMR Rabbit pAb knockout (KO) HeLa cells, using HMMR Rabbit pAb antibody (CAB12445) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
![Anti-HMMR Antibody [KO Validated] (CAB12445)](https://cdn11.bigcommerce.com/s-h68l9z2lnx/product_images/i/820/A12445_3__32512.jpg) | Immunofluorescence analysis of U2OS cells using HMMR antibody (CAB12445). Blue: DAPI for nuclear staining. |
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