Anti-Histone H2A.Z Antibody (CAB4599)
- SKU:
- CAB4599
- Product type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- H2A.Z-1
- Synonyms:
- H2A.z
- Synonyms:
- H2A/z
- Synonyms:
- H2AZ
Frequently bought together:
Description
| 抗体名: | Histone H2A.Z Rabbit mAb |
| 抗体コード: | CAB4599 |
| サイズ: | 20uL, 50uL, 100uL |
| 同義語: | H2A.Z-1, H2A.z, H2A/z, H2AZ |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | A synthesized peptide derived from human Histone H2A.Z |
| 申し込み: | WB |
| 推奨される希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | HeLa, 293T, U-87MG, Mouse lung, Mouse testis, Mouse brain, Rat lung, Rat testis |
| 免疫原: | A synthesized peptide derived from human Histone H2A.Z |
| 精製方法: | Affinity purification |
| 保管所: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 3015 |
| Uniprot: | P0C0S5 |
| 計算された分子量: | 13kDa |
| 観察された分子量: | 15KDa |
| UniProt Protein Function: | H2AZ: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. H2A or its variant H2AFZ forms an heterodimer with H2B. H2AFZ interacts with INCENP. Belongs to the histone H2A family. |
| UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: 4q23 Cellular Component: Barr body; nuclear heterochromatin; nucleus Molecular Function:chromatin DNA binding; nucleosomal DNA binding; protein binding Biological Process: chromatin silencing; positive regulation of transcription from RNA polymerase II promoter |
| NCBI Summary: | Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent member of the histone H2A family that is distinct from other members of the family. Studies in mice have shown that this particular histone is required for embryonic development and indicate that lack of functional histone H2A leads to embryonic lethality. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P0C0S5 |
| NCBI GenInfo Identifier: | 83288408 |
| NCBI Gene ID: | 3015 |
| NCBI Accession: | P0C0S5.2 |
| UniProt Secondary Accession: | P0C0S5,P17317, Q6I9U0, B2RD56, |
| UniProt Related Accession: | P0C0S5 |
| Molecular Weight: | 14kDa |
| NCBI Full Name: | Histone H2A.Z |
| NCBI Synonym Full Names: | H2A histone family member Z |
| NCBI Official Symbol: | H2AFZ |
| NCBI Official Synonym Symbols: | H2AZ; H2A.z; H2A/z; H2A.Z-1 |
| NCBI Protein Information: | histone H2A.Z |
| UniProt Protein Name: | Histone H2A.Z |
| UniProt Gene Name: | H2AFZ |