Anti-HINT1 Antibody (CAB10221)[KO Validated]
- SKU:
- CAB10221
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Frequently bought together:
Description
抗体名: | Anti-HINT1 Antibody [KO Validated] |
抗体コード: | CAB10221 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IF |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-126 of human HINT1 (NP_005331.1). |
申し込み: | WB IF |
推奨希釈: | WB 1:1000 - 1:2000 IF 1:50 - 1:200 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | 22Rv1, HeLa, H460, K-562, Mouse kidney, Mouse liver, Rat kidney, Rat liver |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-126 of human HINT1 (NP_005331.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MADE IAKA QVAR PGGD TIFG KIIR KEIP AKII FEDD RCLA FHDI SPQA PTHF LVIP KKHI SQIS VAED DDES LLGH LMIV GKKC AADL GLNK GYRM VVNE GSDG GQSV YHVH LHVL GGRQ MHWP PG |
遺伝子ID: | 3094 |
Uniprot: | P49773 |
セルラーロケーション: | Cytoplasm, Nucleus |
計算された分子量: | 13kDa |
観察された分子量: | 14kDa |
同義語: | HINT1, HINT, NMAN, PKCI-1, PRKCNH1 |
バックグラウンド: | This gene encodes a protein that hydrolyzes purine nucleotide phosphoramidates substrates, including AMP-morpholidate, AMP-N-alanine methyl ester, AMP-alpha-acetyl lysine methyl ester, and AMP-NH2. The encoded protein interacts with these substrates via a histidine triad motif. This gene is considered a tumor suppressor gene. In addition, mutations in this gene can cause autosomal recessive neuromyotonia and axonal neuropathy. There are several related pseudogenes on chromosome 7. Several transcript variants have been observed. |
UniProt Protein Function: | HINT1: Hydrolyzes adenosine 5'-monophosphoramidate substrates such as AMP-morpholidate, AMP-N-alanine methyl ester, AMP-alpha- acetyl lysine methyl ester and AMP-NH2. Belongs to the HINT family. |
UniProt Protein Details: | Protein type:Hydrolase; EC 3.-.-.-; Cytoskeletal Chromosomal Location of Human Ortholog: 5q31.2 Cellular Component: cytoskeleton; histone deacetylase complex; cytoplasm; plasma membrane; nucleus Molecular Function:protein kinase C binding; hydrolase activity; nucleotide binding Biological Process: transcription, DNA-dependent; regulation of transcription, DNA-dependent; purine ribonucleotide catabolic process; signal transduction Disease: Neuromyotonia And Axonal Neuropathy, Autosomal Recessive |
NCBI Summary: | The protein encoded by this gene can hydrolyze substrates such as AMP-morpholidate, AMP-N-alanine methyl ester, AMP-alpha-acetyl lysine methyl ester, and AMP-NH2. The encoded protein interacts with these substrates via a histidine triad motif, which is part of the loop that binds to the substrate. This gene has been found to be a tumor suppressing gene. Several transcript variants, but only one of them protein-coding, have been found for this gene. [provided by RefSeq, Dec 2012] |
UniProt Code: | P49773 |
NCBI GenInfo Identifier: | 1708543 |
NCBI Gene ID: | 3094 |
NCBI Accession: | P49773.2 |
UniProt Secondary Accession: | P49773,Q9H5W8, |
UniProt Related Accession: | P49773 |
Molecular Weight: | 126 |
NCBI Full Name: | Histidine triad nucleotide-binding protein 1 |
NCBI Synonym Full Names: | histidine triad nucleotide binding protein 1 |
NCBI Official Symbol: | HINT1 |
NCBI Official Synonym Symbols: | HINT; NMAN; PKCI-1; PRKCNH1 |
NCBI Protein Information: | histidine triad nucleotide-binding protein 1; protein kinase C inhibitor 1; adenosine 5'-monophosphoramidase; protein kinase C-interacting protein 1 |
UniProt Protein Name: | Histidine triad nucleotide-binding protein 1 |
UniProt Synonym Protein Names: | Adenosine 5'-monophosphoramidase; Protein kinase C inhibitor 1; Protein kinase C-interacting protein 1; PKCI-1 |
Protein Family: | Adenylylsulfatase |
UniProt Gene Name: | HINT1 |
UniProt Entry Name: | HINT1_HUMAN |
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