Anti-HHLA2 Antibody (CAB13262)
- SKU:
- CAB13262
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-HHLA2 Antibody |
| 抗体コード: | CAB13262 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 30-200 of human HHLA2 (NP_009003.1). |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| 反応性: | Human |
| ポジティブサンプル: |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 30-200 of human HHLA2 (NP_009003.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | IYVP MNEQ IVIG RLDE DIIL PSSF ERGS EVVI HWKY QDSY KVHS YYKG SDHL ESQD PRYA NRTS LFYN EIQN GNAS LFFR RVSL LDEG IYTC YVGT AIQV ITNK VVLK VGVF LTPV MKYE KRNT NSFL ICSV LSVY PRPI ITWK MDNT PISE NNME ETGS LDSF SINS PLN |
| 遺伝子ID: | 11148 |
| Uniprot: | Q9UM44 |
| セルラーロケーション: | Membrane, Single-pass type I membrane protein |
| 計算された分子量: | 39kDa/46kDa |
| 観察された分子量: | Refer to figures |
| 同義語: | HHLA2, B7-H5, B7-H7, B7H7, B7y |
| バックグラウンド: | This gene encodes a protein ligand found on the surface of monocytes. The encoded protein is thought to regulate cell-mediated immunity by binding to a receptor on T lymphocytes and inhibiting the proliferation of these cells. Alternate splicing results in multiple transcript variants. |
| UniProt Protein Function: | HHLA2: Through interaction with TMIGD2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade. Up-regulated in antigen-presenting cells in response to inflammation. Induced in dendritic cells in response to IFNG, poly(I:C) or heat-killed Listeria monocytogenes (at protein level). Interacts with TMIGD2. 2 isoforms of the human protein are produced by alternative splicing |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 3q13.13 Cellular Component: integral to membrane Molecular Function:protein binding Biological Process: positive regulation of cytokine production; T cell costimulation; positive regulation of activated T cell proliferation |
| NCBI Summary: | This gene encodes a protein ligand found on the surface of monocytes. The encoded protein is thought to regulate cell-mediated immunity by binding to a receptor on T lymphocytes and inhibiting the proliferation of these cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013] |
| UniProt Code: | Q9UM44 |
| NCBI GenInfo Identifier: | 5901964 |
| NCBI Gene ID: | 11148 |
| NCBI Accession: | NP_009003.1 |
| UniProt Secondary Accession: | Q9UM44,Q9NWQ6, B4DKN2, D3DN60, |
| UniProt Related Accession: | Q9UM44 |
| Molecular Weight: | |
| NCBI Full Name: | HERV-H LTR-associating protein 2 isoform a |
| NCBI Synonym Full Names: | HERV-H LTR-associating 2 |
| NCBI Official Symbol: | HHLA2 |
| NCBI Official Synonym Symbols: | B7H7; B7-H7 |
| NCBI Protein Information: | HERV-H LTR-associating protein 2 |
| UniProt Protein Name: | HERV-H LTR-associating protein 2 |
| UniProt Synonym Protein Names: | Human endogenous retrovirus-H long terminal repeat-associating protein 2 |
| Protein Family: | HERV-H LTR-associating protein |
| UniProt Gene Name: | HHLA2 |
| UniProt Entry Name: | HHLA2_HUMAN |
 | Immunohistochemistry of paraffin-embedded human colon using HHLA2 antibody (CAB13262) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human lung using HHLA2 antibody (CAB13262) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human stomach using HHLA2 antibody (CAB13262) at dilution of 1:100 (40x lens). |
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