| UniProt Protein Function: | Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. |
| NCBI Summary: | This gen encodes a member of the HERC protein family. This protein stimulates guanine nucleotide exchange on ARF1 and Rab proteins. This protein may be involved in membrane transport processes. [provided by RefSeq, Mar 2012] |
| UniProt Code: | Q15751 |
| NCBI GenInfo Identifier: | 126131099 |
| NCBI Gene ID: | 8925 |
| NCBI Accession: | NP_003913.3 |
| UniProt Secondary Accession: | Q15751,Q8IW65, |
| UniProt Related Accession: | Q15751 |
| Molecular Weight: | 532,228 Da |
| NCBI Full Name: | probable E3 ubiquitin-protein ligase HERC1 |
| NCBI Synonym Full Names: | HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 |
| NCBI Official Symbol: | HERC1 |
| NCBI Official Synonym Symbols: | p532; p619; MDFPMR |
| NCBI Protein Information: | probable E3 ubiquitin-protein ligase HERC1 |
| UniProt Protein Name: | Probable E3 ubiquitin-protein ligase HERC1 |
| UniProt Synonym Protein Names: | HECT domain and RCC1-like domain-containing protein 1; HECT-type E3 ubiquitin transferase HERC1; p532; p619 |
| Protein Family: | Probable E3 ubiquitin-protein ligase |
| UniProt Gene Name: | HERC1 |
