Anti-HCRTR2 Antibody (CAB3057)
- SKU:
- CAB3057
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-HCRTR2 Antibody |
| 抗体コード: | CAB3057 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 380-444 of human HCRTR2 (NP_001517.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | U-87MG, 293T, Mouse brain, Mouse heart, Mouse kidney |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 380-444 of human HCRTR2 (NP_001517.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | SCCC LGVH HRQE DRLT RGRT STES RKSL TTQI SNFD NISK LSEQ VVLT SIST LPAA NGAG PLQN W |
| 遺伝子ID: | 3062 |
| Uniprot: | O43614 |
| セルラーロケーション: | Cell membrane, Multi-pass membrane protein |
| 計算された分子量: | 50kDa |
| 観察された分子量: | 50kDa |
| 同義語: | HCRTR2, OX2R |
| バックグラウンド: | The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein binds the hypothalamic neuropeptides orexin A and orexin B. A related gene (HCRTR1) encodes a G-protein coupled receptor that selectively binds orexin A. |
| UniProt Protein Function: | HCRTR2: Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides. Belongs to the G-protein coupled receptor 1 family. |
| UniProt Protein Details: | Protein type:GPCR, family 1; Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral Chromosomal Location of Human Ortholog: 6p12 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:neuropeptide receptor activity; orexin receptor activity; peptide hormone binding; peptide binding Biological Process: synaptic transmission; neuropeptide signaling pathway; circadian sleep/wake cycle process; feeding behavior; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); cellular response to hormone stimulus; regulation of circadian sleep/wake cycle, sleep |
| NCBI Summary: | The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein binds the hypothalamic neuropeptides orexin A and orexin B. A related gene (HCRTR1) encodes a G-protein coupled receptor that selectively binds orexin A. [provided by RefSeq, Jan 2009] |
| UniProt Code: | O43614 |
| NCBI GenInfo Identifier: | 206729885 |
| NCBI Gene ID: | 3062 |
| NCBI Accession: | O43614.2 |
| UniProt Secondary Accession: | O43614,P58308, |
| UniProt Related Accession: | O43614 |
| Molecular Weight: | 444 |
| NCBI Full Name: | Orexin receptor type 2 |
| NCBI Synonym Full Names: | hypocretin (orexin) receptor 2 |
| NCBI Official Symbol: | HCRTR2 |
| NCBI Official Synonym Symbols: | OX2R |
| NCBI Protein Information: | orexin receptor type 2; ox2-R; ox-2-R; orexin type-2 receptor; hypocretin receptor type 2 |
| UniProt Protein Name: | Orexin receptor type 2 |
| UniProt Synonym Protein Names: | Hypocretin receptor type 2 |
| UniProt Gene Name: | HCRTR2 |
| UniProt Entry Name: | OX2R_HUMAN |
 | Western blot analysis of extracts of various cell lines, using HCRTR2 antibody (CAB3057) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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