Anti-HCN1 Antibody (CAB16198)
- SKU:
- CAB16198
- Product type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| 抗体名: | Anti-HCN1 Antibody |
| 抗体コード: | CAB16198 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF |
| 反応性: | Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic peptide of human HCN1 |
| 申し込み: | WB IF |
| 推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| 反応性: | Mouse, Rat |
| ポジティブサンプル: | Mouse brain, Rat brain |
| 免疫原: | A synthetic peptide of human HCN1 |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 348980 |
| Uniprot: | O60741 |
| セルラーロケーション: | Cell membrane, Multi-pass membrane protein |
| 計算された分子量: | 98kDa |
| 観察された分子量: | 113kDa |
| 同義語: | HCN1, BCNG-1, BCNG1, EIEE24, HAC-2 |
| バックグラウンド: | The membrane protein encoded by this gene is a hyperpolarization-activated cation channel that contributes to the native pacemaker currents in heart and neurons. The encoded protein can homodimerize or heterodimerize with other pore-forming subunits to form a potassium channel. This channel may act as a receptor for sour tastes. |
| UniProt Protein Function: | HCN1: Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Activated by cAMP, and at 10-100 times higher concentrations, also by cGMP. May mediate responses to sour stimuli. Belongs to the potassium channel HCN family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 5p12 Cellular Component: axon; integral to plasma membrane; dendrite; integral to membrane; plasma membrane Molecular Function:identical protein binding; voltage-gated potassium channel activity; intracellular cAMP activated cation channel activity; potassium channel activity; voltage-gated sodium channel activity; cAMP binding Biological Process: synaptic transmission; regulation of membrane potential; apical protein localization; retinal cone cell development; potassium ion transport Disease: Epileptic Encephalopathy, Early Infantile, 24 |
| NCBI Summary: | The membrane protein encoded by this gene is a hyperpolarization-activated cation channel that contributes to the native pacemaker currents in heart and neurons. The encoded protein can homodimerize or heterodimerize with other pore-forming subunits to form a potassium channel. This channel may act as a receptor for sour tastes. [provided by RefSeq, Oct 2011] |
| UniProt Code: | O60741 |
| NCBI GenInfo Identifier: | 229462966 |
| NCBI Gene ID: | 348980 |
| NCBI Accession: | O60741.3 |
| UniProt Related Accession: | O60741 |
| Molecular Weight: | 890 |
| NCBI Full Name: | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 |
| NCBI Synonym Full Names: | hyperpolarization activated cyclic nucleotide-gated potassium channel 1 |
| NCBI Official Symbol: | HCN1 |
| NCBI Official Synonym Symbols: | BCNG1; HAC-2; BCNG-1; EIEE24 |
| NCBI Protein Information: | potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1; brain cyclic nucleotide gated channel 1; brain cyclic nucleotide-gated channel 1 |
| UniProt Protein Name: | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 |
| UniProt Synonym Protein Names: | Brain cyclic nucleotide-gated channel 1; BCNG-1 |
| Protein Family: | Anaphase-promoting complex |
| UniProt Gene Name: | HCN1 |
| UniProt Entry Name: | HCN1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using HCN1 antibody (CAB16198) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunofluorescence analysis of NIH/3T3 cells using HCN1 Rabbit pAb (CAB16198) at dilution of 1:100. Blue: DAPI for nuclear staining. |
View AllClose