Anti-HBG1 Antibody (CAB14989)

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SKU:
CAB14989
Product type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction
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Description

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抗体名:Anti-HBG1 Antibody
抗体コード:CAB14989
抗体サイズ:20uL, 50uL, 100uL
申し込み:WB IHC
反応性:Human, Mouse, Rat
宿主種:Rabbit
免疫原:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human HBG1 (NP_000550.2).
申し込み:WB IHC
推奨希釈:WB 1:500 - 1:2000 IHC 1:100 - 1:200
反応性:Human, Mouse, Rat
ポジティブサンプル:LO2, K-562
免疫原:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human HBG1 (NP_000550.2).
精製方法:Affinity purification
ストレージバッファ:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
アイソタイプ:IgG
順序:MGHF TEED KATI TSLW GKVN VEDA GGET LGRL LVVY PWTQ RFFD SFGN LSSA SAIM GNPK VKAH GKKV LTSL GDAT KHLD DLKG TFAQ LSEL HCDK LHVD
遺伝子ID:3047
Uniprot:P69891
セルラーロケーション:
計算された分子量:16kDa
観察された分子量:12KDa
同義語:HBG1, HBG-T2, HBGA, HBGR, HSGGL1, PRO2979
バックグラウンド:The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5'-epsilon -- gamma-G -- gamma-A -- delta -- beta--3'.
UniProt Protein Function:HBG1: Gamma chains make up the fetal hemoglobin F, in combination with alpha chains. Belongs to the globin family.
UniProt Protein Details:

Protein type:Carrier

Chromosomal Location of Human Ortholog: 11p15.5

Cellular Component: cytosol

Biological Process: blood coagulation

Disease: Fetal Hemoglobin Quantitative Trait Locus 1

NCBI Summary:The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5'-epsilon -- gamma-G -- gamma-A -- delta -- beta--3'. [provided by RefSeq, Jul 2008]
UniProt Code:P69891
NCBI GenInfo Identifier:56749860
NCBI Gene ID:3047
NCBI Accession:P69891.2
UniProt Secondary Accession:P69891,P02096, P62027, Q549G1, Q8TDA1, Q96FH7,
UniProt Related Accession:P69891
Molecular Weight:16,140 Da
NCBI Full Name:Hemoglobin subunit gamma-1
NCBI Synonym Full Names:hemoglobin subunit gamma 1
NCBI Official Symbol:HBG1  
NCBI Official Synonym Symbols:HBGA; HBGR; HBG-T2; HSGGL1; PRO2979  
NCBI Protein Information:hemoglobin subunit gamma-1
UniProt Protein Name:Hemoglobin subunit gamma-1
UniProt Synonym Protein Names:Gamma-1-globin; Hb F Agamma; Hemoglobin gamma-1 chain; Hemoglobin gamma-A chain
Protein Family:Hemoglobin
UniProt Gene Name:HBG1  
UniProt Entry Name:HBG1_HUMAN
Anti-HBG1 Antibody (CAB14989)Western blot analysis of extracts of various cell lines, using HBG1 Rabbit pAb (CAB14989) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
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