| UniProt Protein Function: | HBEGF: Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor. |
| UniProt Protein Details: | Protein type:Cell surface; Membrane protein, integral Chromosomal Location of Human Ortholog: 5q23 Cellular Component: extracellular space; cell surface; integral to plasma membrane; extracellular region; plasma membrane Molecular Function:heparin binding; growth factor activity; epidermal growth factor receptor binding Biological Process: epidermal growth factor receptor signaling pathway; positive regulation of keratinocyte migration; muscle development; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; positive regulation of smooth muscle cell proliferation; negative regulation of elastin biosynthetic process; pathogenesis; signal transduction; positive regulation of cell growth; regulation of heart contraction; positive regulation of protein kinase B signaling cascade; positive regulation of cell proliferation; innate immune response; positive regulation of cell migration; wound healing, spreading of epidermal cells |
| UniProt Code: | Q99075 |
| NCBI GenInfo Identifier: | 544477 |
| NCBI Gene ID: | 1839 |
| NCBI Accession: | Q99075.1 |
| UniProt Secondary Accession: | Q99075,B2R821, |
| UniProt Related Accession: | Q99075 |
| Molecular Weight: | Calculated MW: 23kDaObserved MW: 23kDa |
| NCBI Full Name: | Proheparin-binding EGF-like growth factor |
| NCBI Synonym Full Names: | heparin-binding EGF-like growth factor |
| NCBI Official Symbol: | HBEGF |
| NCBI Official Synonym Symbols: | DTR; DTS; DTSF; HEGFL |
| NCBI Protein Information: | proheparin-binding EGF-like growth factor; heparin-binding epidermal growth factor; diphtheria toxin receptor (heparin-binding EGF-like growth factor); diphtheria toxin receptor (heparin-binding epidermal growth factor-like growth factor) |
| UniProt Protein Name: | Proheparin-binding EGF-like growth factor |
| UniProt Synonym Protein Names: | Diphtheria toxin receptor; DT-R |
| Protein Family: | Proheparin-binding EGF-like growth factor |
| UniProt Gene Name: | HBEGF |
| UniProt Entry Name: | HBEGF_HUMAN |
