| UniProt Protein Function: | USP7: an enzyme that removes ubiquitin from its protein substrates. Binds to the herpes virus protein VMW110 that may therefore modulate its substrate specificity or activity to stabilize viral proteins. Regulates MDM2 and has a dynamic role in the p53-MDM2 pathway. Is reported to deubiquitinate and stabilize p53. |
| UniProt Protein Details: | Protein type:Ubiquitin-specific protease; Protease; EC 3.4.19.12; Ubiquitin conjugating system Chromosomal Location of Human Ortholog: 16p13.3 Cellular Component: nuclear body; PML body; cytosol; nucleus Molecular Function:protein C-terminus binding; protein binding; p53 binding; cysteine-type endopeptidase activity; ubiquitin protein ligase binding; ubiquitin-specific protease activity; transcription factor binding Biological Process: proteasomal ubiquitin-dependent protein catabolic process; protein deubiquitination; maintenance of DNA methylation; viral reproduction; regulation of transcription factor activity; inhibition of NF-kappaB transcription factor; transcription-coupled nucleotide-excision repair; multicellular organismal development; histone deubiquitination |
| UniProt Code: | Q93009 |
| NCBI GenInfo Identifier: | 212276477 |
| NCBI Gene ID: | 7874 |
| NCBI Accession: | Q93009.2 |
| UniProt Secondary Accession: | Q93009,A6NMY8, B7Z815, H0Y3G8, |
| UniProt Related Accession: | Q93009 |
| Molecular Weight: | 1102 |
| NCBI Full Name: | Ubiquitin carboxyl-terminal hydrolase 7 |
| NCBI Synonym Full Names: | ubiquitin specific peptidase 7 (herpes virus-associated) |
| NCBI Official Symbol: | USP7 |
| NCBI Official Synonym Symbols: | TEF1; HAUSP |
| NCBI Protein Information: | ubiquitin carboxyl-terminal hydrolase 7; ubiquitin thioesterase 7; deubiquitinating enzyme 7; ubiquitin-specific-processing protease 7; herpesvirus-associated ubiquitin-specific protease; Herpes virus-associated ubiquitin-specific protease; ubiquitin spec |
| UniProt Protein Name: | Ubiquitin carboxyl-terminal hydrolase 7 |
| UniProt Synonym Protein Names: | Deubiquitinating enzyme 7; Herpesvirus-associated ubiquitin-specific protease; Ubiquitin thioesterase 7; Ubiquitin-specific-processing protease 7 |
| UniProt Gene Name: | USP7 |
| UniProt Entry Name: | UBP7_HUMAN |
