Anti-HAND1 Antibody (CAB9855)
- SKU:
- CAB9855
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Description
抗体名: | Anti-HAND1 Antibody |
抗体コード: | CAB9855 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 16-215 of human HAND1 (NP_004812.1). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human, Mouse |
ポジティブサンプル: | SH-SY5Y, A-549, NIH/3T3 |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 16-215 of human HAND1 (NP_004812.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | PHPA HPML HEPF LFGP ASRC HQER PYFQ SWLL SPAD AAPD FPAG GPPP AAAA AATA YGPD ARPG QSPG RLEA LGGR LGRR KGSG PKKE RRRT ESIN SAFA ELRE CIPN VPAD TKLS KIKT LRLA TSYI AYLM DVLA KDAQ SGDP EAFK AELK KADG GRES KRKR ELQQ HEGF PPAL GPVE KRIK GRTG WPQQ VWAL ELNQ |
遺伝子ID: | 9421 |
Uniprot: | O96004 |
セルラーロケーション: | Nucleus, nucleolus, nucleoplasm |
計算された分子量: | 23kDa |
観察された分子量: | 30kDa |
同義語: | HAND1, Hxt, Thing1, bHLHa27, eHand |
バックグラウンド: | The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, it has been suggested that this transcription factor may be required for early trophoblast differentiation. |
UniProt Protein Function: | HAND1: Transcription factor that plays an essential role in both trophoblast-giant cells differentiation and in cardiac morphogenesis. In the adult, could be required for ongoing expression of cardiac-specific genes. Binds the DNA sequence 5'- NRTCTG-3' (non-canonical E-box). |
UniProt Protein Details: | Protein type:Transcription factor; Nucleolus; Cell development/differentiation; DNA-binding Chromosomal Location of Human Ortholog: 5q33 Cellular Component: cytoplasm; nucleus Molecular Function:bHLH transcription factor binding; identical protein binding; protein binding; transcription coactivator activity; transcription corepressor activity; transcription factor binding Biological Process: angiogenesis; blastocyst development; embryonic heart tube development; heart development; heart looping; negative regulation of transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter; trophectodermal cell differentiation; ventricular cardiac muscle morphogenesis |
NCBI Summary: | The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, it has been suggested that this transcription factor may be required for early trophoblast differentiation. [provided by RefSeq, Jul 2008] |
UniProt Code: | O96004 |
NCBI GenInfo Identifier: | 10720015 |
NCBI Gene ID: | 9421 |
NCBI Accession: | O96004.1 |
UniProt Related Accession: | O96004 |
Molecular Weight: | 23,627 Da |
NCBI Full Name: | Heart- and neural crest derivatives-expressed protein 1 |
NCBI Synonym Full Names: | heart and neural crest derivatives expressed 1 |
NCBI Official Symbol: | HAND1 |
NCBI Official Synonym Symbols: | Hxt; eHand; Thing1; bHLHa27 |
NCBI Protein Information: | heart- and neural crest derivatives-expressed protein 1 |
UniProt Protein Name: | Heart- and neural crest derivatives-expressed protein 1 |
UniProt Synonym Protein Names: | Class A basic helix-loop-helix protein 27; bHLHa27; Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1; eHAND |
Protein Family: | Heart- and neural crest derivatives-expressed protein |
UniProt Gene Name: | HAND1 |
UniProt Entry Name: | HAND1_HUMAN |