| UniProt Protein Function: | H2AFV: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division. Belongs to the histone H2A family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 7p13 Cellular Component: nuclear chromatin; nucleosome; nucleus Molecular Function:DNA binding; protein heterodimerization activity Biological Process: chromatin silencing |
| NCBI Summary: | Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H2A family. Several transcript variants encoding different isoforms, have been identified for this gene. [provided by RefSeq, Oct 2015] |
| UniProt Code: | Q71UI9 |
| NCBI GenInfo Identifier: | |
| NCBI Gene ID: | 94239 |
| NCBI Accession: | NP_036544.1 |
| UniProt Secondary Accession: | Q71UI9,Q59GV8, Q6PK98, A6NFA8, A6NKY0, A6NN01, A8MQC5 |
| UniProt Related Accession: | Q71UI9 |
| Molecular Weight: | 29.5 kDa |
| NCBI Full Name: | |
| NCBI Synonym Full Names: | H2A histone family member V |
| NCBI Official Symbol: | H2AFV |
| NCBI Official Synonym Symbols: | H2AV; H2A.Z-2 |
| NCBI Protein Information: | histone H2A.V |
| UniProt Protein Name: | Histone H2A.V |
| UniProt Synonym Protein Names: | H2A.F/Z |
| Protein Family: | Histone |
| UniProt Gene Name: | H2AFV |
| UniProt Entry Name: | H2AV_HUMAN |
