Anti-GZMH Antibody (CAB6154)
- SKU:
- CAB6154
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-GZMH Antibody |
| 抗体コード: | CAB6154 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-246 of human GZMH (NP_219491.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | MCF7, Mouse spleen, Mouse liver |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-246 of human GZMH (NP_219491.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | EIIG GHEA KPHS RPYM AFVQ FLQE KSRK RCGG ILVR KDFV LTAA HCQG SSIN VTLG AHNI KEQE RTQQ FIPV KRPI PHPA YNPK NFSN DIML LQLE RKAK WTTA VRPL RLPS SKAQ VKPG QLCS VAGW GYVS MSTL ATTL QEVL LTVQ KDCQ CERL FHGN YSRA TEIC VGDP KKTQ TGFK GDSG GPLV CKDV AQGI LSYG NKKG TPPG VYIK VSHF LPWI KRTM KRL |
| 遺伝子ID: | 2999 |
| Uniprot: | P20718 |
| セルラーロケーション: | Cytoplasmic granule |
| 計算された分子量: | 12kDa/17kDa/27kDa |
| 観察された分子量: | 37kDa |
| 同義語: | GZMH, CCP-X, CGL-2, CSP-C, CTLA1, CTSGL2 |
| バックグラウンド: | This gene encodes a member of the peptidase S1 family of serine proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a chymotrypsin-like protease. This protein is reported to be constitutively expressed in the NK (natural killer) cells of the immune system and may play a role in the cytotoxic arm of the innate immune response by inducing target cell death and by directly cleaving substrates in pathogen-infected cells. This gene is present in a gene cluster with another member of the granzyme subfamily on chromosome 14. |
| UniProt Protein Function: | GZMF: Cytotoxic chymotrypsin-like serine protease with preference for bulky and aromatic residues at the P1 position and acidic residues at the P3' and P4' sites. Probably necessary for target cell lysis in cell-mediated immune responses. Belongs to the peptidase S1 family. Granzyme subfamily. |
| UniProt Protein Details: | Protein type:Protease; EC 3.4.21.- Chromosomal Location of Human Ortholog: 14q11.2 Cellular Component: cytoplasm; intracellular membrane-bound organelle; membrane Molecular Function:serine-type endopeptidase activity Biological Process: immune response; protein processing |
| NCBI Summary: | This gene encodes a member of the peptidase S1 family of serine proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a chymotrypsin-like protease. This protein is reported to be constitutively expressed in the NK (natural killer) cells of the immune system and may play a role in the cytotoxic arm of the innate immune response by inducing target cell death and by directly cleaving substrates in pathogen-infected cells. This gene is present in a gene cluster with another member of the granzyme subfamily on chromosome 14. [provided by RefSeq, Nov 2015] |
| UniProt Code: | P20718 |
| NCBI GenInfo Identifier: | 121590 |
| NCBI Gene ID: | 2999 |
| NCBI Accession: | P20718.1 |
| UniProt Secondary Accession: | P20718,Q6XGZ0, Q6XGZ1, G3V2C5, |
| UniProt Related Accession: | P20718 |
| Molecular Weight: | 12,609 Da |
| NCBI Full Name: | Granzyme H |
| NCBI Synonym Full Names: | granzyme H |
| NCBI Official Symbol: | GZMH |
| NCBI Official Synonym Symbols: | CCP-X; CGL-2; CSP-C; CTLA1; CTSGL2 |
| NCBI Protein Information: | granzyme H |
| UniProt Protein Name: | Granzyme H |
| UniProt Synonym Protein Names: | CCP-X; Cathepsin G-like 2; CTSGL2; Cytotoxic T-lymphocyte proteinase; Cytotoxic serine protease C; CSP-C |
| Protein Family: | Granzyme |
| UniProt Gene Name: | GZMH |
| UniProt Entry Name: | GRAH_HUMAN |
 | Western blot analysis of extracts of various cell lines, using GZMH Antibody (CAB6154) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 30s. |
View AllClose