Anti-GYPC Antibody (CAB1232)
- SKU:
- CAB1232
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
抗体名: | Anti-GYPC Antibody |
抗体コード: | CAB1232 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IF |
反応性: | Human, Mouse |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-128 of human GYPC (NP_002092.1). |
申し込み: | WB IF |
推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
反応性: | Human, Mouse |
ポジティブサンプル: | HepG2, HL-60, Mouse heart |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-128 of human GYPC (NP_002092.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MWST RSPN STAW PLSL EPDP GMAS ASTT MHTT TIAE PDPG MSGW PDGR METS TPTI MDIV VIAG VIAA VAIV LVSL LFVM LRYM YRHK GTYH TNEA KGTE FAES ADAA LQGD PALQ DAGD SSRK EYFI |
遺伝子ID: | 2995 |
Uniprot: | P04921 |
セルラーロケーション: | Cell membrane, Single-pass type III membrane protein |
計算された分子量: | 11kDa/13kDa |
観察された分子量: | 34kDa |
同義語: | GYPC, CD236, CD236R, GE, GE:GPC:GPD:GYPD, GPC, GPD, GYPD, PAS-2, PAS-2 |
バックグラウンド: | Glycophorin C (GYPC) is an integral membrane glycoprotein. It is a minor species carried by human erythrocytes, but plays an important role in regulating the mechanical stability of red cells. A number of glycophorin C mutations have been described. The Gerbich and Yus phenotypes are due to deletion of exon 3 and 2, respectively. The Webb and Duch antigens, also known as glycophorin D, result from single point mutations of the glycophorin C gene. The glycophorin C protein has very little homology with glycophorins A and B. Alternate splicing results in multiple transcript variants. |
UniProt Protein Function: | GYPC: This protein is a minor sialoglycoprotein in human erythrocyte membranes. The blood group Gerbich antigens and receptors for Plasmodium falciparum merozoites are most likely located within the extracellular domain. Glycophorin-C plays an important role in regulating the stability of red cells. Belongs to the glycophorin-C family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 2q14-q21 Cellular Component: cortical cytoskeleton; membrane; integral to plasma membrane; plasma membrane Molecular Function:protein binding Disease: Malaria, Susceptibility To; Blood Group, Gerbich System |
NCBI Summary: | Glycophorin C (GYPC) is an integral membrane glycoprotein. It is a minor species carried by human erythrocytes, but plays an important role in regulating the mechanical stability of red cells. A number of glycophorin C mutations have been described. The Gerbich and Yus phenotypes are due to deletion of exon 3 and 2, respectively. The Webb and Duch antigens, also known as glycophorin D, result from single point mutations of the glycophorin C gene. The glycophorin C protein has very little homology with glycophorins A and B. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012] |
UniProt Code: | P04921 |
NCBI GenInfo Identifier: | 121407 |
NCBI Gene ID: | 2995 |
NCBI Accession: | P04921.1 |
UniProt Secondary Accession: | P04921,Q53SV9, Q92642, B2R522, |
UniProt Related Accession: | P04921 |
Molecular Weight: | 128 |
NCBI Full Name: | Glycophorin-C |
NCBI Synonym Full Names: | glycophorin C (Gerbich blood group) |
NCBI Official Symbol: | GYPC |
NCBI Official Synonym Symbols: | GE; GPC; GPD; GYPD; CD236; PAS-2; CD236R; PAS-2' |
NCBI Protein Information: | glycophorin-C; glycophorin-D; glycoconnectin; glycoprotein beta; sialoglycoprotein D |
UniProt Protein Name: | Glycophorin-C |
UniProt Synonym Protein Names: | Glycoconnectin; Glycophorin-D; GPD; Glycoprotein beta; PAS-2'; Sialoglycoprotein D; CD_antigen: CD236 |
Protein Family: | Glycophorin |
UniProt Gene Name: | GYPC |
UniProt Entry Name: | GLPC_HUMAN |
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