Anti-GTPBP4 Antibody (CAB4565)

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SKU:
CAB4565
Product type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
GTPBP4
Synonyms:
CRFG
Synonyms:
NGB
Synonyms:
NOG1
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Description

抗体名:GTPBP4 Rabbit pAb
抗体コード:CAB4565
サイズ:20uL, 50uL, 100uL
同義語:GTPBP4, CRFG, NGB, NOG1
申し込み:WB, IHC, IF
反応性:Human, Mouse, Rat
宿主種:Rabbit
免疫原:Recombinant fusion protein containing a sequence corresponding to amino acids 385-634 of human GTPBP4 (NP_036473.2).
申し込み:WB, IHC, IF
推奨される希釈:WB 1:1000 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
反応性:Human, Mouse, Rat
ポジティブサンプル:293T, HeLa, Jurkat, MCF7, HT-1080, K-562
免疫原:Recombinant fusion protein containing a sequence corresponding to amino acids 385-634 of human GTPBP4 (NP_036473.2).
精製方法:Affinity purification
保管所:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
アイソタイプ:IgG
順序:RKRM ETEE SRKK RERD LELE MGDD YILD LQKY WDLM NLSE KHDK IPEI WEGH NIAD YIDP AIMK KLEE LEKE EELR TAAG EYDS VSES EDEE MLEI RQLA KQIR EKKK LKIL ESKE KNTQ GPRM PRTA KKVQ RTVL EKEM RSLG VDMD DKDD AHYA VQAR RSRS ITRK RKRE DSAP PSSV ARSG SCSR TPRD VSGL RDVK MVKK AKTM MKNA QKKM NRLG KKGE ADRH VFDM KPKH LLSG KRKA GKKD RR
遺伝子ID:23560
Uniprot:Q9BZE4
セルラーロケーション:Nucleus, nucleolus
計算された分子量:60kDa/68kDa/73kDa
観察された分子量:74kDa
UniProt Protein Function:GTPBP4: Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the GTP1/OBG family. NOG subfamily.
UniProt Protein Details:

Protein type:Nucleolus; RNA-binding; Ribosomal

Chromosomal Location of Human Ortholog: 10p15-p14

Cellular Component: Golgi apparatus; nuclear membrane; membrane; perinuclear region of cytoplasm; cytoplasm; nucleolus; nucleus

Molecular Function:GTPase activity; protein binding; GTP binding

Biological Process: osteoblast differentiation; negative regulation of cell proliferation; protein stabilization; metabolic process; negative regulation of DNA replication; ribosome biogenesis and assembly; negative regulation of protein ubiquitination; regulation of cyclin-dependent protein kinase activity; negative regulation of cell-cell adhesion; negative regulation of cell migration; negative regulation of collagen binding

NCBI Summary:GTP-binding proteins are GTPases and function as molecular switches that can flip between two states: active, when GTP is bound, and inactive, when GDP is bound. 'Active' in this context usually means that the molecule acts as a signal to trigger other events in the cell. When an extracellular ligand binds to a G-protein-linked receptor, the receptor changes its conformation and switches on the trimeric G proteins that associate with it by causing them to eject their GDP and replace it with GTP. The switch is turned off when the G protein hydrolyzes its own bound GTP, converting it back to GDP. But before that occurs, the active protein has an opportunity to diffuse away from the receptor and deliver its message for a prolonged period to its downstream target. [provided by RefSeq, Jul 2008]
UniProt Code:Q9BZE4
NCBI GenInfo Identifier:17368711
NCBI Gene ID:23560
NCBI Accession:Q9BZE4.3
UniProt Related Accession:Q9BZE4
Molecular Weight:
NCBI Full Name:Nucleolar GTP-binding protein 1
NCBI Synonym Full Names:GTP binding protein 4
NCBI Official Symbol:GTPBP4  
NCBI Official Synonym Symbols:NGB; CRFG; NOG1  
NCBI Protein Information:nucleolar GTP-binding protein 1
UniProt Protein Name:Nucleolar GTP-binding protein 1
UniProt Synonym Protein Names:Chronic renal failure gene protein; GTP-binding protein NGB
Protein Family:Noggin
UniProt Gene Name:GTPBP4  
UniProt Entry Name:NOG1_HUMAN
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