Anti-GRPR Antibody (CAB2940)
- SKU:
- CAB2940
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-GRPR Antibody |
| 抗体コード: | CAB2940 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 235-384 of human GRPR (NP_005305.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | U-87MG, SGC-7901, A-549, MCF7, Mouse brain, Mouse pancreas, Rat brain |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 235-384 of human GRPR (NP_005305.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | KNLI QSAY NLPV EGNI HVKK QIES RKRL AKTV LVFV GLFA FCWL PNHV IYLY RSYH YSEV DTSM LHFV TSIC ARLL AFTN SCVN PFAL YLLS KSFR KQFN TQLL CCQP GLII RSHS TGRS TTCM TSLK STNP SVAT FSLI NGNI CHER YV |
| 遺伝子ID: | 2925 |
| Uniprot: | P30550 |
| セルラーロケーション: | Cell membrane, Multi-pass membrane protein |
| 計算された分子量: | 43kDa |
| 観察された分子量: | 43kDa |
| 同義語: | GRPR, BB2, BB2R |
| バックグラウンド: | Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene. |
| UniProt Protein Function: | GRPR: Receptor for gastrin releasing peptide (GRP). This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. |
| UniProt Protein Details: | Protein type:GPCR, family 1; Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral Chromosomal Location of Human Ortholog: Xp22.2 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:bombesin receptor activity; peptide receptor activity, G-protein coupled Biological Process: G-protein coupled receptor protein signaling pathway; cell proliferation; bombesin receptor signaling pathway; regulation of cell proliferation |
| NCBI Summary: | Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P30550 |
| NCBI GenInfo Identifier: | 232185 |
| NCBI Gene ID: | 2925 |
| NCBI Accession: | P30550.1 |
| UniProt Secondary Accession: | P30550,B2R910, |
| UniProt Related Accession: | P30550,AAB27329 |
| Molecular Weight: | 384 |
| NCBI Full Name: | Gastrin-releasing peptide receptor |
| NCBI Synonym Full Names: | gastrin-releasing peptide receptor |
| NCBI Official Symbol: | GRPR |
| NCBI Official Synonym Symbols: | BB2 |
| NCBI Protein Information: | gastrin-releasing peptide receptor; GRP-R; bombesin receptor 2; GRP-preferring bombesin receptor |
| UniProt Protein Name: | Gastrin-releasing peptide receptor |
| UniProt Synonym Protein Names: | GRP-preferring bombesin receptor |
| Protein Family: | Gastrin-releasing peptide receptor |
| UniProt Gene Name: | GRPR |
| UniProt Entry Name: | GRPR_HUMAN |
 | Western blot analysis of extracts of various cell lines, using GRPR antibody (CAB2940) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s. |
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