Anti-GRM7 Antibody (CAB10488)
- SKU:
- CAB10488
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
Description
抗体名: | Anti-GRM7 Antibody |
抗体コード: | CAB10488 |
抗体サイズ: | 20uL, 50 uL |
申し込み: | WB |
反応性: | Human |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 220-410 of human GRM7 (NP_870989.1). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human |
ポジティブサンプル: |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 220-410 of human GRM7 (NP_870989.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | YVST LASE GSYG EKGV ESFT QISK EAGG LCIA QSVR IPQE RKDR TIDF DRII KQLL DTPN SRAV VIFA NDED IKQI LAAA KRAD QVGH FLWV GSDS WGSK INPL HQHE DIAE GAIT IQPK RATV EGFD AYFT SRTL ENNR RNVW FAEY WEEN FNCK LTIS GSKK EDTD RKCT GQER IGKD SNYE QEGK VQF |
遺伝子ID: | 2917 |
Uniprot: | Q14831 |
セルラーロケーション: | Cell membrane, Multi-pass membrane protein |
計算された分子量: | 101kDa/102kDa/103kDa |
観察された分子量: | Refer to figures |
同義語: | GRM7, GLUR7, GPRC1G, MGLU7, MGLUR7, PPP1R87 |
バックグラウンド: | L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into three groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5, and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene. |
UniProt Protein Function: | mGluR7: Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity. Belongs to the G-protein coupled receptor 3 family. 5 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, multi-pass; GPCR, family 3; Receptor, GPCR; Membrane protein, integral Chromosomal Location of Human Ortholog: 3p26.1-p25.1 Cellular Component: asymmetric synapse; axon; cell cortex; dendrite; dendritic shaft; integral to membrane; integral to plasma membrane; plasma membrane; postsynaptic membrane; presynaptic active zone; presynaptic membrane; receptor complex Molecular Function:calcium channel regulator activity; glutamate receptor activity; group III metabotropic glutamate receptor activity Biological Process: behavioral fear response; metabotropic glutamate receptor, adenylate cyclase inhibiting pathway; negative regulation of cAMP biosynthetic process; negative regulation of glutamate secretion; regulation of synaptic transmission, glutamatergic; sensory perception of sound; synaptic transmission |
NCBI Summary: | L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into three groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5, and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009] |
UniProt Code: | Q14831 |
NCBI GenInfo Identifier: | 2495078 |
NCBI Gene ID: | 2917 |
NCBI Accession: | Q14831.1 |
UniProt Secondary Accession: | Q14831,Q8NFS2, Q8NFS3, Q8NFS4, |
UniProt Related Accession: | Q14831 |
Molecular Weight: | 101,302 Da |
NCBI Full Name: | Metabotropic glutamate receptor 7 |
NCBI Synonym Full Names: | glutamate metabotropic receptor 7 |
NCBI Official Symbol: | GRM7 |
NCBI Official Synonym Symbols: | GLUR7; MGLU7; GPRC1G; MGLUR7; PPP1R87 |
NCBI Protein Information: | metabotropic glutamate receptor 7 |
UniProt Protein Name: | Metabotropic glutamate receptor 7 |
Protein Family: | Metabotropic glutamate receptor |
UniProt Gene Name: | GRM7 |
UniProt Entry Name: | GRM7_HUMAN |