Anti-GRM3 Antibody (CAB2538)
- SKU:
- CAB2538
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-GRM3 Antibody |
| 抗体コード: | CAB2538 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 23-170 of human GRM3 (NP_000831.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | Raji, Mouse brain |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 23-170 of human GRM3 (NP_000831.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | LGDH NFLR REIK IEGD LVLG GLFP INEK GTGT EECG RINE DRGI QRLE AMLF AIDE INKD DYLL PGVK LGVH ILDT CSRD TYAL EQSL EFVR ASLT KVDE AEYM CPDG SYAI QENI PLLI AGVI GGSY SSVS IQVA NLLR LFQI PQIS |
| 遺伝子ID: | 2913 |
| Uniprot: | Q14832 |
| セルラーロケーション: | Cell membrane, Multi-pass membrane protein |
| 計算された分子量: | 60kDa/98kDa |
| 観察された分子量: | 112kDa |
| 同義語: | GRM3, GLUR3, GPRC1C, MGLUR3, mGlu3 |
| バックグラウンド: | L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. |
| UniProt Protein Function: | mGluR3: metabotropic glutamate receptor 3, a G-protein coupled receptor for glutamate. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Receptor, GPCR; GPCR, family 3; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 7q21.1-q21.2 Cellular Component: presynaptic membrane; postsynaptic membrane; axon; integral to plasma membrane; postsynaptic density; dendritic spine; plasma membrane Molecular Function:G-protein coupled receptor activity; group II metabotropic glutamate receptor activity; group III metabotropic glutamate receptor activity; calcium channel regulator activity; glutamate receptor activity Biological Process: synaptic transmission; regulation of synaptic transmission, glutamatergic; negative regulation of adenylate cyclase activity; metabotropic glutamate receptor, adenylate cyclase inhibiting pathway |
| NCBI Summary: | L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q14832 |
| NCBI GenInfo Identifier: | 76803803 |
| NCBI Gene ID: | 2913 |
| NCBI Accession: | Q14832.2 |
| UniProt Secondary Accession: | Q14832,Q2PNZ6, Q75MV4, Q75N17, Q86YG6, Q8TBH9, |
| UniProt Related Accession: | Q14832 |
| Molecular Weight: | 879 |
| NCBI Full Name: | Metabotropic glutamate receptor 3 |
| NCBI Synonym Full Names: | glutamate receptor, metabotropic 3 |
| NCBI Official Symbol: | GRM3 |
| NCBI Official Synonym Symbols: | GLUR3; mGlu3; GPRC1C; MGLUR3 |
| NCBI Protein Information: | metabotropic glutamate receptor 3; glutamate metabotropic receptor 3 |
| UniProt Protein Name: | Metabotropic glutamate receptor 3 |
| Protein Family: | Metabotropic glutamate receptor |
| UniProt Gene Name: | GRM3 |
| UniProt Entry Name: | GRM3_HUMAN |
 | Western blot analysis of extracts of various cell lines, using GRM3 antibody (CAB2538) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
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