Anti-GRM2 Antibody (CAB10561)
- SKU:
- CAB10561
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-GRM2 Antibody |
| 抗体コード: | CAB10561 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 410-540 of human GRM2 (NP_000830.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:1000 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | U-251MG, HeLa, HepG2, Mouse liver, Mouse kidney |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 410-540 of human GRM2 (NP_000830.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MRPV NGRR LYKD FVLN VKFD APFR PADT HNEV RFDR FGDG IGRY NIFT YLRA GSGR YRYQ KVGY WAEG LTLD TSLI PWAS PSAG PLPA SRCS EPCL QNEV KSVQ PGEV CCWL CIPC QPYE YRLD EFTC ADC |
| 遺伝子ID: | 2912 |
| Uniprot: | Q14416 |
| セルラーロケーション: | Cell junction, Cell membrane, Cell projection, Multi-pass membrane protein, dendrite, synapse |
| 計算された分子量: | 95kDa |
| 観察された分子量: | 110kDa |
| 同義語: | GRM2, GLUR2, GPRC1B, MGLUR2, mGlu2 |
| バックグラウンド: | L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Two transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | mGluR2: Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization. Belongs to the G-protein coupled receptor 3 family. |
| UniProt Protein Details: | Protein type:GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Chromosomal Location of Human Ortholog: 3p21.2 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:calcium channel regulator activity; G-protein coupled receptor activity; glutamate receptor activity; protein binding Biological Process: metabotropic glutamate receptor signaling pathway; negative regulation of adenylate cyclase activity; regulation of synaptic transmission, glutamatergic; synaptic transmission |
| NCBI Summary: | L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2017] |
| UniProt Code: | Q14416 |
| NCBI GenInfo Identifier: | 76803802 |
| NCBI Gene ID: | 2912 |
| NCBI Accession: | Q14416.2 |
| UniProt Secondary Accession: | Q14416,Q14CU5, Q52MC6, Q9H3N6, B0M0K7, |
| UniProt Related Accession: | Q14416 |
| Molecular Weight: | 96kDa |
| NCBI Full Name: | Metabotropic glutamate receptor 2 |
| NCBI Synonym Full Names: | glutamate metabotropic receptor 2 |
| NCBI Official Symbol: | GRM2 |
| NCBI Official Synonym Symbols: | GLUR2; mGlu2; GPRC1B; MGLUR2 |
| NCBI Protein Information: | metabotropic glutamate receptor 2 |
| UniProt Protein Name: | Metabotropic glutamate receptor 2 |
| Protein Family: | Metabotropic glutamate receptor |
| UniProt Gene Name: | GRM2 |
 | Western blot analysis of extracts of various cell lines, using GRM2 antibody (CAB10561) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
View AllClose