Anti-GRIP1 Antibody (CAB16503)

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SKU:
CAB16503
Product type:
Antibody
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
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Description

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抗体名:Anti-GRIP1 Antibody
抗体コード:CAB16503
抗体サイズ:20uL, 50uL, 100uL
申し込み:WB
反応性:Rat
宿主種:Rabbit
免疫原:Recombinant fusion protein containing a sequence corresponding to amino acids 700-950 of human GRIP1 (NP_001171545.1).
申し込み:WB
推奨希釈:WB 1:500 - 1:2000
反応性:Rat
ポジティブサンプル:Rat brain
免疫原:Recombinant fusion protein containing a sequence corresponding to amino acids 700-950 of human GRIP1 (NP_001171545.1).
精製方法:Affinity purification
ストレージバッファ:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
アイソタイプ:IgG
順序:KKQT DAQS ASSP KKFP ISSH LSDL GDVE EDSS PAQK PGKL SDMY PSTV PSVD SAVD SWDG SAID TSYG TQGT SFQA SGYN FNTY DWRS PKQR GSLS PVTK PRSQ TYPD VGLS YEDW DRST ASGF AGAA DSAE TEQE ENFW SQAL EDLE TCGQ SGIL RELE ATIM SGST MSLN HEAP TPRS QLGR QASF QERS SSRP HYSQ TTRS NTLP SDVG RKSV TLRK MKQE IKEI MSPT PVEL HKVT LYKD SDME DFG
遺伝子ID:23426
Uniprot:Q9Y3R0
セルラーロケーション:Cell junction, Cytoplasmic vesicle, Endoplasmic reticulum, postsynaptic cell membrane, synapse
計算された分子量:116kDa/120kDa/122kDa
観察された分子量:132kDa
同義語:GRIP1, GRIP
バックグラウンド:This gene encodes a member of the glutamate receptor interacting protein family. The encoded scaffold protein binds to and mediates the trafficking and membrane organization of a number of transmembrane proteins. Alternatively spliced transcript variants encoding different isoforms have been described.
UniProt Protein Function:GRIP1: a scaffold protein for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific locations in neurons. Interacts with EphA7, EphB2, KIF5A, -B, -C, GluR2, -3, GRIPAP1, liprin A1, PPFIA4, FRAS1, and PTPRF.
UniProt Protein Details:

Protein type:Adaptor/scaffold

Chromosomal Location of Human Ortholog: 12q14.3

Cellular Component: postsynaptic membrane; recycling endosome; neuron projection; endoplasmic reticulum; cytoplasmic membrane-bound vesicle; dendrite; plasma membrane; cytosol; cell junction; lipid raft

Molecular Function:protein C-terminus binding; protein binding; receptor signaling complex scaffold activity; androgen receptor binding; transcription coactivator activity; beta-catenin binding; glucocorticoid receptor binding

Biological Process: synaptic transmission; protein localization; positive regulation of transcription, DNA-dependent; androgen receptor signaling pathway; dendrite development

Disease: Fraser Syndrome

NCBI Summary:This gene encodes a member of the glutamate receptor interacting protein family. The encoded scaffold protein binds to and mediates the trafficking and membrane organization of a number of transmembrane proteins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, May 2010]
UniProt Code:Q9Y3R0
NCBI GenInfo Identifier:313104231
NCBI Gene ID:23426
NCBI Accession:Q9Y3R0.3
UniProt Secondary Accession:Q9Y3R0,Q1RLM0, C9JT59,
UniProt Related Accession:Q9Y3R0
Molecular Weight:1128
NCBI Full Name:Glutamate receptor-interacting protein 1
NCBI Synonym Full Names:glutamate receptor interacting protein 1
NCBI Official Symbol:GRIP1  
NCBI Official Synonym Symbols:GRIP  
NCBI Protein Information:glutamate receptor-interacting protein 1
UniProt Protein Name:Glutamate receptor-interacting protein 1
Protein Family:GRIP1-associated protein
UniProt Gene Name:GRIP1  
UniProt Entry Name:GRIP1_HUMAN
Anti-GRIP1 Antibody (CAB16503)Western blot analysis of extracts of rat brain, using GRIP1 antibody (CAB16503) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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