Anti-GRB14 Antibody (CAB2742)
- SKU:
- CAB2742
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-GRB14 Antibody |
| 抗体コード: | CAB2742 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant protein of human GRB14 |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:500 - 1:1000 IHC 1:25 - 1:100 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | Human fetal intestine |
| 免疫原: | Recombinant protein of human GRB14 |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 2888 |
| Uniprot: | Q14449 |
| セルラーロケーション: | Cytoplasm, Endosome membrane, Golgi apparatus membrane, Peripheral membrane protein |
| 計算された分子量: | 51kDa/60kDa |
| 観察された分子量: | 61kDa |
| 同義語: | GRB14 |
| バックグラウンド: | The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. This protein likely has an inhibitory effect on receptor tyrosine kinase signaling and, in particular, on insulin receptor signaling. This gene may play a role in signaling pathways that regulate growth and metabolism. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | GRB14: Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal. Belongs to the GRB7/10/14 family. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 2q22-q24 Cellular Component: Golgi membrane; intracellular membrane-bound organelle; cytoplasm; plasma membrane; endosome membrane; cytosol Molecular Function:SH3/SH2 adaptor activity Biological Process: positive regulation of signal transduction; signal transduction; blood coagulation; leukocyte migration |
| NCBI Summary: | The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. This protein likely has an inhibitory effect on receptor tyrosine kinase signaling and, in particular, on insulin receptor signaling. This gene may play a role in signaling pathways that regulate growth and metabolism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014] |
| UniProt Code: | Q14449 |
| NCBI GenInfo Identifier: | 59802920 |
| NCBI Gene ID: | 2888 |
| NCBI Accession: | Q14449.2 |
| UniProt Secondary Accession: | Q14449,Q7Z6I1, B7Z7F9, |
| UniProt Related Accession: | Q14449 |
| Molecular Weight: | 540 |
| NCBI Full Name: | Growth factor receptor-bound protein 14 |
| NCBI Synonym Full Names: | growth factor receptor-bound protein 14 |
| NCBI Official Symbol: | GRB14 |
| NCBI Protein Information: | growth factor receptor-bound protein 14; GRB14 adapter protein |
| UniProt Protein Name: | Growth factor receptor-bound protein 14 |
| UniProt Synonym Protein Names: | GRB14 adapter protein |
| Protein Family: | Growth factor receptor-bound protein |
| UniProt Gene Name: | GRB14 |
| UniProt Entry Name: | GRB14_HUMAN |
 | Western blot analysis of extracts of human fetal intestine, using GRB14 antibody (CAB2742). Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
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