Anti-GRB10 Antibody (CAB0634)
- SKU:
- CAB0634
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-GRB10 Antibody |
| 抗体コード: | CAB0634 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human GRB10 (NP_005302.3). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:1000 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | HeLa |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human GRB10 (NP_005302.3). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MALA GCPD SFLH HPYY QDKV EQTP RSQQ DPAG PGLP AQSD RLAN HQED DVDL EALV NDMN ASLE SLYS ACSM QSDT VPLL QNGQ HARS QPRA SGPP RSIQ |
| 遺伝子ID: | 2887 |
| Uniprot: | Q13322 |
| セルラーロケーション: | Cytoplasm |
| 計算された分子量: | 60kDa/62kDa/66kDa/67kDa |
| 観察された分子量: | 70kDa |
| 同義語: | GRB10, GRB-IR, Grb-10, IRBP, MEG1, RSS |
| バックグラウンド: | The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner, with expression observed from the paternal allele in the brain, and from the maternal allele in the placental trophoblasts. Alternatively spliced transcript variants encoding different isoforms have been identified. |
| UniProt Protein Function: | GRB10: an adaptor protein that inhibits insulin-stimulated IRS-PI (3)K-Akt signaling pathway by disrupting the association of IRS with the insulin receptor. Also binds activated PDGFR and EGFR. Preferentially localizes to the mitochondria, modulating the anti-apoptotic activity of mitochondrial Raf-1. Can translocate to the plasma membrane and lamellipodia. Three alternatively spliced isoforms have been described. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 7p12.2 Cellular Component: cytoplasm; plasma membrane; cytosol Molecular Function:protein binding; SH3/SH2 adaptor activity; insulin receptor binding Biological Process: negative regulation of glucose import; negative regulation of Wnt receptor signaling pathway; insulin-like growth factor receptor signaling pathway; insulin receptor signaling pathway; negative regulation of insulin receptor signaling pathway; negative regulation of phosphorylation; positive regulation of phosphorylation; positive regulation of vascular endothelial growth factor receptor signaling pathway; response to insulin stimulus; negative regulation of glycogen biosynthetic process |
| NCBI Summary: | The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner, with expression observed from the paternal allele in the brain, and from the maternal allele in the placental trophoblasts. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2010] |
| UniProt Code: | Q13322 |
| NCBI GenInfo Identifier: | 6166186 |
| NCBI Gene ID: | 2887 |
| NCBI Accession: | Q13322.2 |
| UniProt Secondary Accession: | Q13322,O00427, O00701, O75222, Q92606, Q92907, Q92948 A4D258, A7VJ95, A8K0E6, D3DVM9, |
| UniProt Related Accession: | Q13322 |
| Molecular Weight: | 66,487 Da |
| NCBI Full Name: | Growth factor receptor-bound protein 10 |
| NCBI Synonym Full Names: | growth factor receptor-bound protein 10 |
| NCBI Official Symbol: | GRB10 |
| NCBI Official Synonym Symbols: | RSS; IRBP; MEG1; GRB-IR; Grb-10 |
| NCBI Protein Information: | growth factor receptor-bound protein 10; GRB10 adapter protein; GRB10 adaptor protein; maternally expressed gene 1; insulin receptor-binding protein Grb-IR |
| UniProt Protein Name: | Growth factor receptor-bound protein 10 |
| UniProt Synonym Protein Names: | GRB10 adapter protein; Insulin receptor-binding protein Grb-IR |
| Protein Family: | Growth factor receptor-bound protein |
| UniProt Gene Name: | GRB10 |
| UniProt Entry Name: | GRB10_HUMAN |
 | Western blot analysis of extracts of HeLa cells, using GRB10 antibody (CAB0634) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
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