Anti-GRAP2 Antibody (CAB8767)
- SKU:
- CAB8767
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-GRAP2 Antibody |
| 抗体コード: | CAB8767 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-330 of human GRAP2 (NP_004801.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | Jurkat |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-330 of human GRAP2 (NP_004801.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MEAV AKFD FTAS GEDE LSFH TGDV LKIL SNQE EWFK AELG SQEG YVPK NFID IQFP KWFH EGLS RHQA ENLL MGKE VGFF IIRA SQSS PGDF SISV RHED DVQH FKVM RDNK GNYF LWTE KFPS LNKL VDYY RTNS ISRQ KQIF LRDR TRED QGHR GNSL DRRS QGGP HLSG AVGE EIRP SMNR KLSD HPPT LPLQ QHQH QPQP PQYA PAPQ QLQQ PPQQ RYLQ HHHF HQER RGGS LDIN DGHC GTGL GSEM NAAL MHRR HTDP VQLQ AAGR VRWA RALY DFEA LEDD ELGF HSGE VVEV LDSS NPSW WTGR LHNK LGLF PANY VAPM TR |
| 遺伝子ID: | 9402 |
| Uniprot: | O75791 |
| セルラーロケーション: | Cytoplasm, Endosome, Nucleus |
| 計算された分子量: | 24kDa/37kDa |
| 観察された分子量: | 38kDa |
| 同義語: | GRAP2, GADS, GRAP-2, GRB2L, GRBLG, GRID, GRPL, GrbX, Grf40, Mona, P38 |
| バックグラウンド: | This gene encodes a member of the GRB2/Sem5/Drk family. This member is an adaptor-like protein involved in leukocyte-specific protein-tyrosine kinase signaling. Like its related family member, GRB2-related adaptor protein (GRAP), this protein contains an SH2 domain flanked by two SH3 domains. This protein interacts with other proteins, such as GRB2-associated binding protein 1 (GAB1) and the SLP-76 leukocyte protein (LCP2), through its SH3 domains. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. |
| UniProt Protein Function: | GADS: Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc. Belongs to the GRB2/sem-5/DRK family. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 22q13.2 Cellular Component: cytoplasm; cytosol; endosome; nucleoplasm; nucleus Molecular Function:protein binding; SH3/SH2 adaptor activity Biological Process: cell-cell signaling; innate immune response; positive regulation of signal transduction; Ras protein signal transduction; T cell costimulation; T cell receptor signaling pathway |
| NCBI Summary: | This gene encodes a member of the GRB2/Sem5/Drk family. This member is an adaptor-like protein involved in leukocyte-specific protein-tyrosine kinase signaling. Like its related family member, GRB2-related adaptor protein (GRAP), this protein contains an SH2 domain flanked by two SH3 domains. This protein interacts with other proteins, such as GRB2-associated binding protein 1 (GAB1) and the SLP-76 leukocyte protein (LCP2), through its SH3 domains. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Apr 2014] |
| UniProt Code: | O75791 |
| NCBI GenInfo Identifier: | 6685489 |
| NCBI Gene ID: | 9402 |
| NCBI Accession: | O75791.1 |
| UniProt Secondary Accession: | O75791,O43726, Q9NRB7, B7Z8I3, |
| UniProt Related Accession: | O75791 |
| Molecular Weight: | 24,382 Da |
| NCBI Full Name: | GRB2-related adapter protein 2 |
| NCBI Synonym Full Names: | GRB2-related adaptor protein 2 |
| NCBI Official Symbol: | GRAP2 |
| NCBI Official Synonym Symbols: | P38; GADS; GRID; GRPL; GrbX; Mona; GRB2L; GRBLG; Grf40; GRAP-2 |
| NCBI Protein Information: | GRB2-related adapter protein 2 |
| UniProt Protein Name: | GRB2-related adapter protein 2 |
| UniProt Synonym Protein Names: | Adapter protein GRID; GRB-2-like protein; GRB2L; GRBLG; GRBX; Grf40 adapter protein; Grf-40; Growth factor receptor-binding protein; Hematopoietic cell-associated adapter protein GrpL; P38; Protein GADS; SH3-SH2-SH3 adapter Mona |
| Protein Family: | GRB2-related adapter protein |
| UniProt Gene Name: | GRAP2 |
| UniProt Entry Name: | GRAP2_HUMAN |
 | Western blot analysis of extracts of Jurkat cells, using GRAP2 antibody (CAB8767) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 20s. |
View AllClose