Anti-Granzyme B Antibody (CAB19592)
- SKU:
- CAB19592
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Death
Frequently bought together:
Description
| 抗体名: | Anti-Granzyme B Antibody |
| 抗体コード: | CAB19592 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | A synthesized peptide derived from human Granzyme B. |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human |
| ポジティブサンプル: | THP-1 |
| 免疫原: | A synthesized peptide derived from human Granzyme B. |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 3002 |
| Uniprot: | P10144 |
| セルラーロケーション: | |
| 計算された分子量: | 25-35kDa |
| 観察された分子量: | 29KDa |
 | Western blot - Granzyme B Rabbit mAb (CAB19592) |
| 同義語: | C11, CCPI, CGL-1, CGL1, CSP-B, CSPB, CTLA1, CTSGL1, HLP, SECT, Granzyme B, GZMB |
| バックグラウンド: | This gene encodes a member of the granzyme subfamily of proteins, part of the peptidase S1 family of serine proteases. The encoded preproprotein is secreted by natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) and proteolytically processed to generate the active protease, which induces target cell apoptosis. This protein also processes cytokines and degrades extracellular matrix proteins, and these roles are implicated in chronic inflammation and wound healing. Expression of this gene may be elevated in human patients with cardiac fibrosis. [provided by RefSeq, Sep 2016] |
| UniProt Protein Function: | GZMB: This enzyme is necessary for target cell lysis in cell- mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis. By staphylococcal enterotoxin A (SEA) in peripheral blood leukocytes. Inactivated by the serine protease inhibitor diisopropylfluorophosphate. Belongs to the peptidase S1 family. Granzyme subfamily. |
| UniProt Protein Details: | Protein type:Apoptosis; EC 3.4.21.79; Protease Chromosomal Location of Human Ortholog: 14q12 Cellular Component: cytoplasm; cytosol; immunological synapse; intracellular membrane-bound organelle; membrane; nucleus Molecular Function:protein binding; serine-type endopeptidase activity; serine-type peptidase activity Biological Process: apoptosis; natural killer cell mediated cytotoxicity; protein processing |
| NCBI Summary: | This gene encodes a member of the granzyme subfamily of proteins, part of the peptidase S1 family of serine proteases. The encoded preproprotein is secreted by natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) and proteolytically processed to generate the active protease, which induces target cell apoptosis. This protein also processes cytokines and degrades extracellular matrix proteins, and these roles are implicated in chronic inflammation and wound healing. Expression of this gene may be elevated in human patients with cardiac fibrosis. [provided by RefSeq, Sep 2016] |
| UniProt Code: | P10144 |
| NCBI GenInfo Identifier: | 317373361 |
| NCBI Gene ID: | 3002 |
| NCBI Accession: | P10144.2 |
| UniProt Secondary Accession: | P10144,Q8N1D2, Q9UCC1, |
| UniProt Related Accession: | P10144 |
| Molecular Weight: | |
| NCBI Full Name: | Granzyme B |
| NCBI Synonym Full Names: | granzyme B |
| NCBI Official Symbol: | GZMB |
| NCBI Official Synonym Symbols: | C11; HLP; CCPI; CGL1; CSPB; SECT; CGL-1; CSP-B; CTLA1; CTSGL1 |
| NCBI Protein Information: | granzyme B |
| UniProt Protein Name: | Granzyme B |
| UniProt Synonym Protein Names: | C11; CTLA-1; Cathepsin G-like 1; CTSGL1; Cytotoxic T-lymphocyte proteinase 2; Lymphocyte protease; Fragmentin-2; Granzyme-2; Human lymphocyte protein; HLP; SECT; T-cell serine protease 1-3E |
| Protein Family: | Granzyme |
| UniProt Gene Name: | GZMB |