Anti-GPX3 Antibody (CAB12956)
- SKU:
- CAB12956
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-GPX3 Antibody |
| 抗体コード: | CAB12956 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant protein of human GPX3. |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | HepG2, Mouse kidney, Mouse liver |
| 免疫原: | Recombinant protein of human GPX3. |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 2878 |
| Uniprot: | P22352 |
| セルラーロケーション: | Secreted |
| 計算された分子量: | 25kDa |
| 観察された分子量: | 25kDa |
| 同義語: | GPX3, GPx-P, GSHPx-3, GSHPx-P |
| バックグラウンド: | This gene product belongs to the glutathione peroxidase family, which functions in the detoxification of hydrogen peroxide. It contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. |
| UniProt Protein Function: | GPX3: Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. Belongs to the glutathione peroxidase family. |
| UniProt Protein Details: | Protein type:Secreted; Other Amino Acids Metabolism - glutathione; Oxidoreductase; Secreted, signal peptide; Lipid Metabolism - arachidonic acid; EC 1.11.1.9 Chromosomal Location of Human Ortholog: 5q33.1 Cellular Component: extracellular region; extracellular space Molecular Function:glutathione peroxidase activity; protein binding; selenium binding; transcription factor binding Biological Process: hydrogen peroxide catabolic process; protein homotetramerization; response to lipid hydroperoxide; response to reactive oxygen species |
| NCBI Summary: | This gene product belongs to the glutathione peroxidase family, which functions in the detoxification of hydrogen peroxide. It contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P22352 |
| NCBI GenInfo Identifier: | 172046796 |
| NCBI Gene ID: | 2878 |
| NCBI Accession: | P22352.2 |
| UniProt Secondary Accession: | P22352,O43787, Q86W78, Q9NZ74, Q9UEL1, |
| UniProt Related Accession: | P22352 |
| Molecular Weight: | 25,552 Da |
| NCBI Full Name: | Glutathione peroxidase 3 |
| NCBI Synonym Full Names: | glutathione peroxidase 3 |
| NCBI Official Symbol: | GPX3 |
| NCBI Official Synonym Symbols: | GPx-P; GSHPx-3; GSHPx-P |
| NCBI Protein Information: | glutathione peroxidase 3 |
| UniProt Protein Name: | Glutathione peroxidase 3 |
| UniProt Synonym Protein Names: | Extracellular glutathione peroxidase; Plasma glutathione peroxidase; GPx-P; GSHPx-P |
| Protein Family: | Probable glutathione peroxidase |
| UniProt Gene Name: | GPX3 |
| UniProt Entry Name: | GPX3_HUMAN |
 | Western blot analysis of extracts of various cell lines, using GPX3 antibody (CAB12956) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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