Anti-GPSM2 Antibody (CAB10553)
- SKU:
- CAB10553
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Frequently bought together:
Description
| 抗体名: | Anti-GPSM2 Antibody |
| 抗体コード: | CAB10553 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 380-490 of human GPSM2 (NP_037428.3). |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:1000 - 1:2000 IHC 1:50 - 1:200 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | B cells, HeLa, Mouse brain, Mouse liver, Mouse kidney |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 380-490 of human GPSM2 (NP_037428.3). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | STNN SIMS ENTE IDSS LNGV RPKL GRRH SMEN MELM KLTP EKVQ NWNS EILA KQKP LIAK PSAK LLFV NRLK GKKY KTNS STKV LQDA SNSI DHRI PNSQ RKIS ADTI GDE |
| 遺伝子ID: | 29899 |
| Uniprot: | P81274 |
| セルラーロケーション: | Cytoplasm, cell cortex |
| 計算された分子量: | 76kDa |
| 観察された分子量: | 76kDa |
| 同義語: | GPSM2, CMCS, DFNB82, LGN, PINS |
| バックグラウンド: | The protein encoded by this gene belongs to a family of proteins that modulate activation of G proteins, which transduce extracellular signals received by cell surface receptors into integrated cellular responses. The N-terminal half of this protein contains 10 copies of leu-gly-asn (LGN) repeat, and the C-terminal half contains 4 GoLoco motifs, which are involved in guanine nucleotide exchange. This protein may play a role in neuroblast division and in the development of normal hearing. Mutations in this gene are associated with autosomal recessive nonsyndromic deafness (DFNB82). Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | GPSM2: Plays an important role in spindle pole orientation. Interacts and contributes to the functional activity of G(i) alpha proteins. Acts to stabilize the apical complex during neuroblast divisions. Interacts with LLGL2. Interacts with INSC/inscuteable and probably with F2RL2. Ubiquitously expressed. Belongs to the GPSM family. |
| UniProt Protein Details: | Protein type:G protein regulator, misc. Chromosomal Location of Human Ortholog: 1p13.3 Cellular Component: cell cortex; cytosol Molecular Function:GDP-dissociation inhibitor activity; identical protein binding; protein binding Biological Process: G-protein coupled receptor protein signaling pathway; maintenance of centrosome localization; mitotic spindle organization and biogenesis Disease: Chudley-mccullough Syndrome |
| NCBI Summary: | The protein encoded by this gene belongs to a family of proteins that modulate activation of G proteins, which transduce extracellular signals received by cell surface receptors into integrated cellular responses. The N-terminal half of this protein contains 10 copies of leu-gly-asn (LGN) repeat, and the C-terminal half contains 4 GoLoco motifs, which are involved in guanine nucleotide exchange. This protein may play a role in neuroblast division and in the development of normal hearing. Mutations in this gene are associated with autosomal recessive nonsyndromic deafness (DFNB82). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016] |
| UniProt Code: | P81274 |
| NCBI GenInfo Identifier: | 294862507 |
| NCBI Gene ID: | 29899 |
| NCBI Accession: | P81274.3 |
| UniProt Secondary Accession: | P81274,Q5T1N8, Q6IBL7, Q8N0Z5, |
| UniProt Related Accession: | P81274 |
| Molecular Weight: | 77kDa |
| NCBI Full Name: | G-protein-signaling modulator 2 |
| NCBI Synonym Full Names: | G protein signaling modulator 2 |
| NCBI Official Symbol: | GPSM2 |
| NCBI Official Synonym Symbols: | LGN; CMCS; PINS; DFNB82 |
| NCBI Protein Information: | G-protein-signaling modulator 2 |
| UniProt Protein Name: | G-protein-signaling modulator 2 |
| UniProt Synonym Protein Names: | Mosaic protein LGN |
| Protein Family: | G-protein-signaling modulator |
| UniProt Gene Name: | GPSM2 |
 | Western blot analysis of extracts of various cell lines, using GPSM2 antibody (CAB10553) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
 | Immunohistochemistry of paraffin-embedded human tonsil using GPSM2 antibody (CAB10553) at dilution of 1:100 (40x lens). |
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