Anti-GPR68 Antibody (CAB7348)
- SKU:
- CAB7348
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-GPR68 Antibody |
| 抗体コード: | CAB7348 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 276-365 of human GPR68 (NP_003476.3). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | HL-60, U-87MG, NIH/3T3, Jurkat, Mouse brain, Mouse spleen, Mouse lung, Rat brain |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 276-365 of human GPR68 (NP_003476.3). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | SFNC VADP VLYC FVSE TTHR DLAR LRGA CLAF LTCS RTGR AREA YPLG APEA SGKS GAQG EEPE LLTK LHPA FQTP NSPG SGGF PTGR LA |
| 遺伝子ID: | 8111 |
| Uniprot: | Q15743 |
| セルラーロケーション: | Cell membrane, Multi-pass membrane protein |
| 計算された分子量: | 41kDa |
| 観察された分子量: | 48kDa |
| 同義語: | GPR68, AI2A6, GPR12A, OGR1 |
| バックグラウンド: | The protein encoded by this gene is a G protein-coupled receptor for sphingosylphosphorylcholine. The encoded protein is a proton-sensing receptor, inactive at pH 7.8 but active at pH 6.8. Mutations in this gene are a cause of amelogenesis imperfecta. |
| UniProt Protein Function: | GPR68: Proton-sensing receptor involved in pH homeostasis. May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. Mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca(2+) mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Function also as a metastasis suppressor gene in prostate cancer. Belongs to the G-protein coupled receptor 1 family. |
| UniProt Protein Details: | Protein type:Tumor suppressor; Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral; Receptor, GPCR Chromosomal Location of Human Ortholog: 14q31 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:G-protein coupled receptor activity Biological Process: G-protein coupled receptor protein signaling pathway; inflammatory response; negative regulation of monocyte differentiation |
| UniProt Code: | Q15743 |
| NCBI GenInfo Identifier: | 3024266 |
| NCBI Gene ID: | 8111 |
| NCBI Accession: | Q15743.1 |
| UniProt Secondary Accession: | Q15743,Q13334, Q4VBB4, Q6IX34, |
| UniProt Related Accession: | Q15743 |
| Molecular Weight: | 365 |
| NCBI Full Name: | Ovarian cancer G-protein coupled receptor 1 |
| NCBI Synonym Full Names: | G protein-coupled receptor 68 |
| NCBI Official Symbol: | GPR68 |
| NCBI Official Synonym Symbols: | OGR1; GPR12A |
| NCBI Protein Information: | ovarian cancer G-protein coupled receptor 1; G-protein coupled receptor 68; sphingosylphosphorylcholine receptor; ovarian cancer G protein-coupled receptor, 1 |
| UniProt Protein Name: | Ovarian cancer G-protein coupled receptor 1 |
| UniProt Synonym Protein Names: | G-protein coupled receptor 68; GPR12A; Sphingosylphosphorylcholine receptor |
| Protein Family: | Ovarian cancer G-protein coupled receptor |
| UniProt Gene Name: | GPR68 |
| UniProt Entry Name: | OGR1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using GPR68 antibody (CAB7348) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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