| UniProt Protein Function: | GPLD1: This protein hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans (GPI-anchor) thus releasing these proteins from the membrane. Belongs to the GPLD1 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Glycan Metabolism - glycosylphosphatidylinositol (GPI)-anchor biosynthesis; Secreted; Secreted, signal peptide; Phospholipase; EC 3.1.4.50 Chromosomal Location of Human Ortholog: 6p22.1 Cellular Component: extracellular space; proteinaceous extracellular matrix; intracellular membrane-bound organelle; lysosomal membrane; cytoplasm; intracellular Molecular Function:glycosylphosphatidylinositol phospholipase D activity; sodium channel regulator activity; phospholipase D activity Biological Process: ossification; GPI anchor release; positive regulation of apoptosis; complement receptor mediated signaling pathway; positive regulation of membrane protein ectodomain proteolysis; phosphatidylcholine metabolic process; negative regulation of cell proliferation; cellular response to insulin stimulus; cell migration during sprouting angiogenesis; insulin receptor signaling pathway; response to glucose stimulus; positive regulation of secretion; chondrocyte differentiation; positive regulation of cytolysis |
| NCBI Summary: | Many proteins are tethered to the extracellular face of eukaryotic plasma membranes by a glycosylphosphatidylinositol (GPI) anchor. The GPI-anchor is a glycolipid found on many blood cells. The protein encoded by this gene is a GPI degrading enzyme. Glycosylphosphatidylinositol specific phospholipase D1 hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans, thereby releasing the attached protein from the plasma membrane. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P80108 |
| NCBI GenInfo Identifier: | 126302583 |
| NCBI Gene ID: | 2822 |
| NCBI Accession: | P80108.3 |
| UniProt Related Accession: | P80108 |
| Molecular Weight: | |
| NCBI Full Name: | Phosphatidylinositol-glycan-specific phospholipase D |
| NCBI Synonym Full Names: | glycosylphosphatidylinositol specific phospholipase D1 |
| NCBI Official Symbol: | GPLD1 |
| NCBI Official Synonym Symbols: | PLD; GPIPLD; PIGPLD; GPIPLDM; PIGPLD1 |
| NCBI Protein Information: | phosphatidylinositol-glycan-specific phospholipase D |
| UniProt Protein Name: | Phosphatidylinositol-glycan-specific phospholipase D |
| UniProt Synonym Protein Names: | Glycoprotein phospholipase D; Glycosyl-phosphatidylinositol-specific phospholipase D; GPI-PLD; GPI-specific phospholipase D |
| UniProt Gene Name: | GPLD1 |
| UniProt Entry Name: | PHLD_HUMAN |
