Anti-GPD1 Antibody (CAB5715)
- SKU:
- CAB5715
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-GPD1 Antibody |
| 抗体コード: | CAB5715 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-349 of human GPD1 (NP_005267.2). |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | Mouse kidney, Mouse skeletal muscle, Rat liver |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-349 of human GPD1 (NP_005267.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MASK KVCI VGSG NWGS AIAK IVGG NAAQ LAQF DPRV TMWV FEED IGGK KLTE IINT QHEN VKYL PGHK LPPN VVAV PDVV QAAE DADI LIFV VPHQ FIGK ICDQ LKGH LKAN ATGI SLIK GVDE GPNG LKLI SEVI GERL GIPM SVLM GANI ASEV ADEK FCET TIGC KDPA QGQL LKEL MQTP NFRI TVVQ EVDT VEIC GALK NVVA VGAG FCDG LGFG DNTK AAVI RLGL MEMI AFAK LFCS GPVS SATF LESC GVAD LITT CYGG RNRK VAEA FART GKSI EQLE KELL NGQK LQGP ETAR ELYS ILQH KGLV DKFP LFMA VYKV CYEG QPVG EFIH CLQN HPEH M |
| 遺伝子ID: | 2819 |
| Uniprot: | P21695 |
| セルラーロケーション: | Cytoplasm |
| 計算された分子量: | 35kDa/37kDa |
| 観察された分子量: | 38kDa |
| 同義語: | GPD1, GPD-C, GPDH-C, HTGTI |
| バックグラウンド: | This gene encodes a member of the NAD-dependent glycerol-3-phosphate dehydrogenase family. The encoded protein plays a critical role in carbohydrate and lipid metabolism by catalyzing the reversible conversion of dihydroxyacetone phosphate (DHAP) and reduced nicotine adenine dinucleotide (NADH) to glycerol-3-phosphate (G3P) and NAD+. The encoded cytosolic protein and mitochondrial glycerol-3-phosphate dehydrogenase also form a glycerol phosphate shuttle that facilitates the transfer of reducing equivalents from the cytosol to mitochondria. Mutations in this gene are a cause of transient infantile hypertriglyceridemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. |
| UniProt Protein Function: | GPD1: Defects in GPD1 are a cause of hypertriglyceridemia, transient infantile (HTGTI). An autosomal recessive disorder characterized by onset of moderate to severe transient hypertriglyceridemia in infancy that normalizes with age. The hypertriglyceridemia is associated with hepatomegaly, moderately elevated transaminases, persistent fatty liver, and the development of hepatic fibrosis. Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. |
| UniProt Protein Details: | Protein type:Oxidoreductase; EC 1.1.1.8; Lipid Metabolism - glycerophospholipid Chromosomal Location of Human Ortholog: 12q13.12 Cellular Component: cytosol Molecular Function:glycerol-3-phosphate dehydrogenase (NAD+) activity Biological Process: phosphatidic acid biosynthetic process; triacylglycerol biosynthetic process Disease: Hypertriglyceridemia, Transient Infantile |
| NCBI Summary: | This gene encodes a member of the NAD-dependent glycerol-3-phosphate dehydrogenase family. The encoded protein plays a critical role in carbohydrate and lipid metabolism by catalyzing the reversible conversion of dihydroxyacetone phosphate (DHAP) and reduced nicotine adenine dinucleotide (NADH) to glycerol-3-phosphate (G3P) and NAD+. The encoded cytosolic protein and mitochondrial glycerol-3-phosphate dehydrogenase also form a glycerol phosphate shuttle that facilitates the transfer of reducing equivalents from the cytosol to mitochondria. Mutations in this gene are a cause of transient infantile hypertriglyceridemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012] |
| UniProt Code: | P21695 |
| NCBI GenInfo Identifier: | 134047785 |
| NCBI Gene ID: | 2819 |
| NCBI Accession: | P21695.4 |
| UniProt Secondary Accession: | P21695,Q8N1B0, F8W1L5, |
| UniProt Related Accession: | P21695 |
| Molecular Weight: | 35,140 Da |
| NCBI Full Name: | Glycerol-3-phosphate dehydrogenase |
| NCBI Synonym Full Names: | glycerol-3-phosphate dehydrogenase 1 |
| NCBI Official Symbol: | GPD1 |
| NCBI Official Synonym Symbols: | GPD-C; HTGTI; GPDH-C |
| NCBI Protein Information: | glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic |
| UniProt Protein Name: | Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic |
| Protein Family: | Glycerol-3-phosphate dehydrogenase |
| UniProt Gene Name: | GPD1 |
| UniProt Entry Name: | GPDA_HUMAN |
 | Western blot analysis of extracts of various cell lines, using GPD1 antibody (CAB5715) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
 | Immunohistochemistry of paraffin-embedded rat heart using GPD1 Antibody (CAB5715) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded rat heart using GPD1 Antibody (CAB5715) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human breast adipocytes using GPD1 Antibody (CAB5715) at dilution of 1:100 (40x lens). |
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