Anti-GP6 Antibody (CAB14999)
- SKU:
- CAB14999
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cardiovascular
Frequently bought together:
Description
| 抗体名: | Anti-GP6 Antibody |
| 抗体コード: | CAB14999 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 200 to the C-terminus of human GP6 (NP_057447.4). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human |
| ポジティブサンプル: | Jurkat, human plasma |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 200 to the C-terminus of human GP6 (NP_057447.4). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | LVVT GTSV TPSR LPTE PPSP VAEF SEAT AELT VSFT NEVF TTET SRSI TASP KESD SPAG PARQ YYTK GNLV RICL GAVI LIIL AGFL AEDW HSRR KRLR HRGR AVQR PLPP LPPL PQTR KSHG GQDG GRQD VHSR GLCS |
| 遺伝子ID: | 51206 |
| Uniprot: | Q9HCN6 |
| セルラーロケーション: | Cell membrane, Single-pass membrane protein |
| 計算された分子量: | 35kDa/36kDa/67kDa |
| 観察された分子量: | 55kDa |
| 同義語: | GP6, BDPLT11, GPIV, GPVI |
| バックグラウンド: | This gene encodes a platelet membrane glycoprotein of the immunoglobulin superfamily. The encoded protein is a receptor for collagen and plays a critical role in collagen-induced platelet aggregation and thrombus formation. The encoded protein forms a complex with the Fc receptor gamma-chain that initiates the platelet activation signaling cascade upon collagen binding. Mutations in this gene are a cause of platelet-type bleeding disorder-11 (BDPLT11). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. |
| UniProt Protein Function: | GPVI: Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma- chain, the Src kinases (likely Fyn/Lyn), the adapter protein LAT and leads to the activation of phospholipase C gamma2. Defects in GP6 are the cause of bleeding disorder platelet-type 11 (BDPLT11). BDPLT11 is a mild to moderate bleeding disorder caused by defective platelet activation and aggregation in response to collagen. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 19q13.4 Cellular Component: cell surface; integral to plasma membrane; plasma membrane Molecular Function:collagen binding; protein binding; transmembrane receptor activity; receptor activity Biological Process: platelet activation; blood coagulation; leukocyte migration; enzyme linked receptor protein signaling pathway Disease: Bleeding Disorder, Platelet-type, 11 |
| NCBI Summary: | This gene encodes a platelet membrane glycoprotein of the immunoglobulin superfamily. The encoded protein is a receptor for collagen and plays a critical role in collagen-induced platelet aggregation and thrombus formation. The encoded protein forms a complex with the Fc receptor gamma-chain that initiates the platelet activation signaling cascade upon collagen binding. Mutations in this gene are a cause of platelet-type bleeding disorder-11 (BDPLT11). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011] |
| UniProt Code: | Q9HCN6 |
| NCBI GenInfo Identifier: | 26985217 |
| NCBI Gene ID: | 51206 |
| NCBI Accession: | AAN86273.1 |
| UniProt Secondary Accession: | Q9HCN6,Q9HCN7, Q9UIF2, |
| UniProt Related Accession: | Q9HCN6 |
| Molecular Weight: | 36,866 Da |
| NCBI Full Name: | glycoprotein VI, partial |
| NCBI Synonym Full Names: | glycoprotein VI (platelet) |
| NCBI Official Symbol: | GP6 |
| NCBI Official Synonym Symbols: | GPIV; GPVI; BDPLT11 |
| NCBI Protein Information: | platelet glycoprotein VI; glycoprotein 6; platelet collagen receptor |
| UniProt Protein Name: | Platelet glycoprotein VI |
| UniProt Synonym Protein Names: | Glycoprotein 6 |
| Protein Family: | Platelet glycoprotein |
| UniProt Gene Name: | GP6 |
| UniProt Entry Name: | GPVI_HUMAN |
 | Western blot analysis of extracts of various cell lines, using GP6 antibody (CAB14999) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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