Anti-GORASP2 Antibody (CAB10383)
- SKU:
- CAB10383
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Developmental Biology
Frequently bought together:
Description
| 抗体名: | Anti-GORASP2 Antibody |
| 抗体コード: | CAB10383 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 353-452 of human GORASP2 (NP_056345.3). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | LO2, HeLa, Jurkat, MCF7, K-562, SW480, Mouse liver |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 353-452 of human GORASP2 (NP_056345.3). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | PGIA PLPL PSEF LPSF PLVP ESSS AASS GELL SSLP PTSN APSD PATT TAKA DAAS SLTV DVTP PTAK APTT VEDR VGDS TPVS EKPV SAAV DANA SESP |
| 遺伝子ID: | 26003 |
| Uniprot: | Q9H8Y8 |
| セルラーロケーション: | Golgi apparatus membrane, Lipid-anchor, Membrane, Peripheral membrane protein |
| 計算された分子量: | 39kDa/47kDa/48kDa |
| 観察された分子量: | 55kDa |
| 同義語: | GORASP2, GOLPH6, GRASP55, GRS2, p59 |
| バックグラウンド: | This gene encodes a member of the Golgi reassembly stacking protein family. These proteins may play a role in the stacking of Golgi cisternae and Golgi ribbon formation, as well as Golgi fragmentation during apoptosis or mitosis. The encoded protein also plays a role in the intracellular transport of transforming growth factor alpha and may function as a molecular chaperone. A pseudogene of this gene is located on the short arm of chromosome 2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. |
| UniProt Protein Function: | GRASP55: a golgi reassembly-stacking protein (GRASP) protein involved in the stacking of Golgi cisternae. May be involved in the process by which Golgi stacks reform after mitotic breakdown. May regulate the intracellular transport and presentation of a defined set of transmembrane proteins, such as the TGF-alpha receptor. Oligomerization of its N-terminal GRASP domain regulates the formation of Golgi stacks, a process that is regulated by phosphorylation within the C-terminal Ser/Pro-rich domain. Forms a RAB2 effector complex with BLZF1 in the medial Golgi. Interacts with members of the p24 cargo receptors. Interacts with CNIH and the cytoplasmic domain of the TGF-alpha receptor, prior its transit in the trans-Golgi. Two alternatively spliced isoforms have been described. |
| UniProt Protein Details: | Protein type:Vesicle; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 2q31.1 Cellular Component: Golgi membrane; Golgi apparatus; membrane Molecular Function:protein binding Biological Process: organelle organization and biogenesis; mitotic cell cycle |
| NCBI Summary: | This gene encodes a member of the Golgi reassembly stacking protein family. These proteins may play a role in the stacking of Golgi cisternae and Golgi ribbon formation, as well as Golgi fragmentation during apoptosis or mitosis. The encoded protein also plays a role in the intracellular transport of transforming growth factor alpha and may function as a molecular chaperone. A pseudogene of this gene is located on the short arm of chromosome 2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011] |
| UniProt Code: | Q9H8Y8 |
| NCBI GenInfo Identifier: | 51316097 |
| NCBI Gene ID: | 26003 |
| NCBI Accession: | Q9H8Y8.3 |
| UniProt Secondary Accession: | Q9H8Y8,Q53TE3, Q96I74, Q96K84, Q9H946, Q9UFW4, B4DKT0 |
| UniProt Related Accession: | Q9H8Y8 |
| Molecular Weight: | 48,674 Da |
| NCBI Full Name: | Golgi reassembly-stacking protein 2 |
| NCBI Synonym Full Names: | golgi reassembly stacking protein 2, 55kDa |
| NCBI Official Symbol: | GORASP2 |
| NCBI Official Synonym Symbols: | p59; GRS2; GOLPH6; GRASP55 |
| NCBI Protein Information: | Golgi reassembly-stacking protein 2; golgi phosphoprotein 6 |
| UniProt Protein Name: | Golgi reassembly-stacking protein 2 |
| UniProt Synonym Protein Names: | Golgi phosphoprotein 6; GOLPH6; Golgi reassembly-stacking protein of 55 kDa; GRASP55; p59 |
| Protein Family: | Golgi reassembly-stacking protein |
| UniProt Gene Name: | GORASP2 |
| UniProt Entry Name: | GORS2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using GORASP2 antibody (CAB10383) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
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