Anti-GNRHR Antibody (CAB2965)
- SKU:
- CAB2965
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-GNRHR Antibody |
| 抗体コード: | CAB2965 |
| 抗体サイズ: | 100µL |
| 申し込み: | WB IHC |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic peptide of human GNRHR |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | 231, mouse testis |
| 免疫原: | A synthetic peptide of human GNRHR |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 2798 |
| Uniprot: | P30968 |
| セルラーロケーション: | Cell membrane, Multi-pass membrane protein |
| 計算された分子量: | 27kDa/37kDa |
| 観察された分子量: | 28kDa |
| 同義語: | GNRHR, GNRHR1, GRHR, HH7, LHRHR, LRHR |
| バックグラウンド: | This gene encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hypogonadotropic hypogonadism (HH). Alternative splicing results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5' region and multiple polyA signals in the 3' region have been identified for this gene. |
| UniProt Protein Function: | GNRHR: Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle- stimulating hormone (FSH). This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol- calcium second messenger system. Isoform 2 may act as an inhibitor of GnRH-R signaling. Defects in GNRHR are a cause of idiopathic hypogonadotropic hypogonadism (IHH). IHH is defined as a deficiency of the pituitary secretion of follicle-stimulating hormone and luteinizing hormone, which results in the impairment of pubertal maturation and of reproductive function. Defects in GNRHR are a cause of fertile eunuch syndrome (FEUNS). Fertile eunuch syndrome is a mild phenotypic form of HH going with the presence of normal testicular size and some degree of spermatogenesis. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Receptor, GPCR; GPCR, family 1; Membrane protein, multi-pass; Membrane protein, integral Chromosomal Location of Human Ortholog: 4q21.2 Cellular Component: membrane; integral to plasma membrane; plasma membrane Molecular Function:gonadotropin-releasing hormone receptor activity; peptide binding Biological Process: G-protein coupled receptor protein signaling pathway; multicellular organismal development Disease: Hypogonadotropic Hypogonadism 7 With Or Without Anosmia |
| NCBI Summary: | This gene encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hypogonadotropic hypogonadism (HH). Alternative splicing results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5' region and multiple polyA signals in the 3' region have been identified for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P30968 |
| NCBI GenInfo Identifier: | 399777 |
| NCBI Gene ID: | 2798 |
| NCBI Accession: | P30968.1 |
| UniProt Secondary Accession: | P30968,O75793, Q14D13, Q92644, |
| UniProt Related Accession: | P30968 |
| Molecular Weight: | 328 |
| NCBI Full Name: | Gonadotropin-releasing hormone receptor |
| NCBI Synonym Full Names: | gonadotropin-releasing hormone receptor |
| NCBI Official Symbol: | GNRHR |
| NCBI Official Synonym Symbols: | HH7; GRHR; LRHR; LHRHR; GNRHR1 |
| NCBI Protein Information: | gonadotropin-releasing hormone receptor; gnRH-R; gnRH receptor; luliberin receptor; type I GnRH receptor; leutinizing-releasing hormone receptor; leutinizing hormone releasing horomone receptor; gonadotropin-releasing hormone (type 1) receptor 1 |
| UniProt Protein Name: | Gonadotropin-releasing hormone receptor |
| Protein Family: | Gonadotropin-releasing hormone receptor |
| UniProt Gene Name: | GNRHR |
| UniProt Entry Name: | GNRHR_HUMAN |
 | Western blot analysis of extracts of various cell lines, using GNRHR antibody (CAB2965). Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
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