Anti-GNAO1 Antibody (CAB2510)
- SKU:
- CAB2510
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
抗体名: | Anti-GNAO1 Antibody |
抗体コード: | CAB2510 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC |
反応性: | Human, Mouse |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 60-180 of human GNAO1 (NP_066268.1). |
申し込み: | WB IHC |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
反応性: | Human, Mouse |
ポジティブサンプル: | Mouse brain, Mouse spinal cord |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 60-180 of human GNAO1 (NP_066268.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | GFSG EDVK QYKP VVYS NTIQ SLAA IVRA MDTL GIEY GDKE RKAD AKMV CDVV SRME DTEP FSAE LLSA MMRL WGDS GIQE CFNR SREY QLND SAKY YLDS LDRI GAAD YQPT EQDI LRTR V |
遺伝子ID: | 2775 |
Uniprot: | P09471 |
セルラーロケーション: | Cell membrane, Lipid-anchor, Membrane |
計算された分子量: | 40kDa |
観察された分子量: | 39kDa |
同義語: | GNAO1, EIEE17, G-ALPHA-o, GNAO, HLA-DQB1, NEDIM |
バックグラウンド: | The protein encoded by this gene represents the alpha subunit of the Go heterotrimeric G-protein signal-transducing complex. Defects in this gene are a cause of early-onset epileptic encephalopathy. Two transcript variants encoding different isoforms have been found for this gene. |
UniProt Protein Function: | G-alpha(o): Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14. Interacts with RGS14. G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Belongs to the G-alpha family. G(i/o/t/z) subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:G protein, heterotrimeric alpha G((i/o/t/z)); G protein; G protein, heterotrimeric Chromosomal Location of Human Ortholog: 16q13 Cellular Component: neuron projection; plasma membrane; heterotrimeric G-protein complex Molecular Function:corticotropin-releasing hormone receptor 1 binding; GTPase activity; signal transducer activity; GTP binding; mu-type opioid receptor binding; metal ion binding; G-protein beta/gamma-subunit binding; GTPase activating protein binding; metabotropic serotonin receptor binding Biological Process: G-protein signaling, coupled to cAMP nucleotide second messenger; response to drug; negative regulation of calcium ion transport; response to hydrogen peroxide; muscle contraction; metabolic process; response to cytokine stimulus; forebrain development; dopamine receptor signaling pathway; response to morphine; locomotory behavior; neurite development; regulation of heart contraction; positive regulation of GTPase activity; aging Disease: Epileptic Encephalopathy, Early Infantile, 17 |
NCBI Summary: | The protein encoded by this gene represents the alpha subunit of the Go heterotrimeric G-protein signal-transducing complex. Defects in this gene are a cause of early-onset epileptic encephalopathy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015] |
UniProt Code: | P09471 |
NCBI GenInfo Identifier: | 232133 |
NCBI Gene ID: | 2775 |
NCBI Accession: | P09471.4 |
UniProt Related Accession: | P09471 |
Molecular Weight: | |
NCBI Full Name: | Guanine nucleotide-binding protein G(o) subunit alpha |
NCBI Synonym Full Names: | G protein subunit alpha o1 |
NCBI Official Symbol: | GNAO1 |
NCBI Official Synonym Symbols: | GNAO; NEDIM; EIEE17; HLA-DQB1; G-ALPHA-o |
NCBI Protein Information: | guanine nucleotide-binding protein G(o) subunit alpha |
UniProt Protein Name: | Guanine nucleotide-binding protein G(o) subunit alpha |
UniProt Gene Name: | GNAO1 |
UniProt Entry Name: | GNAO_HUMAN |