Anti-GNAL Antibody (CAB12804)
- SKU:
- CAB12804
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-GNAL Antibody |
| 抗体コード: | CAB12804 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human GNAL (NP_892023.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:1000 - 1:2000 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | 293T, Mouse kidney |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human GNAL (NP_892023.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MGLC YSLR PLLF GGPG DDPC AASE PPVE DAQP APAP ALAP VRAA ARDT ARTL LPRG GEGS PACA RPKA DKPK EKRQ RTEQ LSAE EREA AKER EAVK EARK VSRG IDRM LRDQ KRDL QQTH |
| 遺伝子ID: | 2774 |
| Uniprot: | P38405 |
| セルラーロケーション: | |
| 計算された分子量: | 20kDa/44kDa/52kDa |
| 観察された分子量: | 44kDa |
| 同義語: | GNAL, DYT25 |
| バックグラウンド: | This gene encodes a stimulatory G protein alpha subunit which mediates odorant signaling in the olfactory epithelium. This protein couples dopamine type 1 receptors and adenosine A2A receptors and is widely expressed in the central nervous system. Mutations in this gene have been associated with dystonia 25 and this gene is located in a susceptibility region for bipolar disorder and schizophrenia. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | G-alpha(olf): Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G(olf) alpha mediates signal transduction within the olfactory neuroepithelium and the basal ganglia. May be involved in some aspect of visual transduction, and in mediating the effect of one or more hormones/neurotransmitters. Belongs to the G-alpha family. G(s) subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:G protein, heterotrimeric alpha G(s); Membrane protein, peripheral; G protein, heterotrimeric Chromosomal Location of Human Ortholog: 18p11.22-p11.21 Cellular Component: plasma membrane Molecular Function:G-protein beta/gamma-subunit binding; GTP binding; GTPase activity; metal ion binding; signal transducer activity Biological Process: adenylate cyclase activation; dopamine receptor, adenylate cyclase activating pathway; G-protein signaling, adenylate cyclase activating pathway; G-protein signaling, adenylate cyclase inhibiting pathway; metabolic process; response to amphetamine; response to caffeine; sensory perception of smell; signal transduction; synaptic transmission Disease: Dystonia 25 |
| NCBI Summary: | This gene encodes a stimulatory G protein alpha subunit which mediates odorant signaling in the olfactory epithelium. This protein couples dopamine type 1 receptors and adenosine A2A receptors and is widely expressed in the central nervous system. Mutations in this gene have been associated with dystonia 25 and this gene is located in a susceptibility region for bipolar disorder and schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013] |
| UniProt Code: | P38405 |
| NCBI GenInfo Identifier: | 585178 |
| NCBI Gene ID: | 2774 |
| NCBI Accession: | P38405.1 |
| UniProt Secondary Accession: | P38405,Q86XU3, B7ZA26, |
| UniProt Related Accession: | P38405 |
| Molecular Weight: | 20,522 Da |
| NCBI Full Name: | Guanine nucleotide-binding protein G(olf) subunit alpha |
| NCBI Synonym Full Names: | G protein subunit alpha L |
| NCBI Official Symbol: | GNAL |
| NCBI Official Synonym Symbols: | DYT25 |
| NCBI Protein Information: | guanine nucleotide-binding protein G(olf) subunit alpha |
| UniProt Protein Name: | Guanine nucleotide-binding protein G(olf) subunit alpha |
| UniProt Synonym Protein Names: | Adenylate cyclase-stimulating G alpha protein, olfactory type |
| UniProt Gene Name: | GNAL |
| UniProt Entry Name: | GNAL_HUMAN |
 | Western blot analysis of extracts of various cell lines, using GNAL antibody (CAB12804) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
View AllClose