Anti-GLP1R Antibody (CAB8547)
- SKU:
- CAB8547
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-GLP1R Antibody |
| 抗体コード: | CAB8547 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF |
| 反応性: | Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 22-116 of human GLP1R (NP_002053.3). |
| 申し込み: | WB IF |
| 推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| 反応性: | Mouse, Rat |
| ポジティブサンプル: | Mouse lung, Rat stomach, Rat lung |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 22-116 of human GLP1R (NP_002053.3). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | GPRP QGAT VSLW ETVQ KWRE YRRQ CQRS LTED PPPA TDLF CNRT FDEY ACWP DGEP GSFV NVSC PWYL PWAS SVPQ GHVY RFCT AEGL WLQK DNS |
| 遺伝子ID: | 2740 |
| Uniprot: | P43220 |
| セルラーロケーション: | Cell membrane, Multi-pass membrane protein |
| 計算された分子量: | 53kDa |
| 観察された分子量: | 53kDa |
| 同義語: | GLP1R, GLP-1, GLP-1-R, GLP-1R |
| バックグラウンド: | This gene encodes a 7-transmembrane protein that functions as a receptor for glucagon-like peptide 1 (GLP-1) hormone, which stimulates glucose-induced insulin secretion. This receptor, which functions at the cell surface, becomes internalized in response to GLP-1 and GLP-1 analogs, and it plays an important role in the signaling cascades leading to insulin secretion. It also displays neuroprotective effects in animal models. Polymorphisms in this gene are associated with diabetes. The protein is an important drug target for the treatment of type 2 diabetes and stroke. Alternative splicing of this gene results in multiple transcript variants. |
| UniProt Protein Function: | GLP1R: This is a receptor for glucagon-like peptide 1. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 2 family. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR; GPCR, family 2 Chromosomal Location of Human Ortholog: 6p21 Cellular Component: cytosol; integral to membrane; intracellular; plasma membrane Molecular Function:glucagon receptor activity; protein binding; transmembrane receptor activity Biological Process: adenylate cyclase activation; cAMP-mediated signaling; cell surface receptor linked signal transduction; elevation of cytosolic calcium ion concentration; energy reserve metabolic process; G-protein coupled receptor protein signaling pathway; learning and/or memory; positive regulation of blood pressure; regulation of heart contraction; regulation of insulin secretion; response to stress |
| NCBI Summary: | This gene encodes a 7-transmembrane protein that functions as a receptor for glucagon-like peptide 1 (GLP-1) hormone, which stimulates glucose-induced insulin secretion. This receptor, which functions at the cell surface, becomes internalized in response to GLP-1 and GLP-1 analogs, and it plays an important role in the signaling cascades leading to insulin secretion. It also displays neuroprotective effects in animal models. Polymorphisms in this gene are associated with diabetes. The protein is an important drug target for the treatment of type 2 diabetes and stroke. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2016] |
| UniProt Code: | P43220 |
| NCBI GenInfo Identifier: | 311033387 |
| NCBI Gene ID: | 2740 |
| NCBI Accession: | P43220.2 |
| UniProt Secondary Accession: | P43220,Q2M229, Q99669, |
| UniProt Related Accession: | P43220 |
| Molecular Weight: | |
| NCBI Full Name: | Glucagon-like peptide 1 receptor |
| NCBI Synonym Full Names: | glucagon like peptide 1 receptor |
| NCBI Official Symbol: | GLP1R |
| NCBI Official Synonym Symbols: | GLP-1; GLP-1R; GLP-1-R |
| NCBI Protein Information: | glucagon-like peptide 1 receptor |
| UniProt Protein Name: | Glucagon-like peptide 1 receptor |
| Protein Family: | Glucagon-like peptide 1 receptor |
| UniProt Gene Name: | GLP1R |
| UniProt Entry Name: | GLP1R_HUMAN |
 | Western blot analysis of extracts of various cell lines, using GLP1R antibody (CAB8547) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunofluorescence analysis of L929 cells using GLP1R antibody (CAB8547) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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